Ankylosing Spondylitis, AS, is a chronic inflammatory disease whose exact causes are not yet entirely clear. However, studies have shown that the combination of genetic, immune system anomalies and environmental factors may be the main cause of the disease. The following is a detailed study of the possible causes of acute spinal disease.
1. Genetic factors
1.1 HLA-B27 Genetics: Strong-relative spinal diseases are closely related to genetic factors, in particular the most significant association with HLA-B27 Genetics. HLA-B27 is a human white cell antigen (HLA) gene located on the sixth pair of chromosomes. About 90 per cent of patients with direct spinal diseases carry HLA-B27 genes, compared to about 6-8 per cent of the general population. Although the presence of HLA-B27 has significantly increased the risk of disease, not all people carrying the gene develop into direct spinal diseases, indicating that other genetic and environmental factors also play an important role. 1.2 Other genetic factors: In addition to HLA-B27, other genes, such as ERAP1, IL23R and CARD9, have been found to be also associated with direct spinachitis. These genes may affect the functional and inflammatory response of the immune system, but their specific mechanisms are still under study.
2. Immunization system anomalies
Straight spinal disease is considered to be an autoimmune disease, i.e. the immune system wrongfully attacks its own organization. In the case of direct spinachitis, the abnormal activation of the immune system has led to chronic inflammation of the spinal column and the hip. 2.1 Self-immunisation response: HLA-B27 may play a role in the unusual response of the immune system. Studies have shown that HLA-B27 may wrongly present some antigens, leading to the abnormal activation of T-cells and their own immune response. 2.2 Inflammatory cause: In the case of patients with direct spinal disease, the levels of certain inflammatory causes, such as tumour necrosis (TNF-α) and white cell media-17 (IL-17), have increased. These factors play a key role in the inflammation response and may lead to damage to joints and spines.
3. Environmental factors
While genetic factors play an important role in the incidence of direct spinal disease, environmental factors may also affect the incidence and development of disease. 3.1 Infections: Studies suggest that certain bacterial infections may have a catalytic effect in the onset of a strong straight spinal column. For example, intestinal infections can lead to abnormal activation of the immune system, especially among HLA-B27 positive individuals. 3.2 Lifestyle: Lifestyle factors, such as smoking and diet, may affect the severity of vertical spinal disease. Smoking is considered to aggravate symptoms of disease, and a balanced diet and appropriate physical activity may help to manage the symptoms.
4. Microorganisms
In recent years, researchers have begun to focus on the role of intestinal micro-organisms in their own immune diseases. The intestinal microbial group composition of patients with direct spina can differ from that of the healthy population, which may affect the functioning of the immune system and inflammation response.
Straight spinalitis.
