Rheumatism arthritis (RA) is a common chronic inflammatory disease characterized by joint pain, swelling and deformity. In addition to joint symptoms, RAs are often associated with multiple systemic complications, of which anaemia is one of the more common clinical manifestations. The impact of RA on anaemia is multifaceted and involves inflammation, immunization and nutrition.
I. The mechanism for RA to cause anaemia (i) Anemia induced by inflammation (RA) has a chronic inflammation response in patients with inflammation cells, which release a large number of cytofactors, such as tumour cause of death (TNF) and white cell media (IL). These factors interfere with iron metabolism and make iron absorption and use barrier. Inflammation also inhibits the creation of erythrocytes (EPOs) and affects the generation of red cells. In addition, inflammation leads to reduced erythrocyte life expectancy, which further exacerbates anaemia. (ii) Anemia due to the immune response Anomalous immune system of persons with RA, which produces a large number of self-antibodies, such as rheumatism (RF), anti-nucleus (ANA). These antibodies are combined with the surface of the red cell, resulting in increased red cell damage. At the same time, immune compounds are deposited within their veins, and the reagent system is activated, which can cause red cell damage. (iii) Nutritional anaemia, as a result of the effects of the disease, tends to reduce the appetite of patients and to suffer from inadequate nutrient intake. In particular, deficiencies in nutrients such as iron, folic acid and vitamin B12 can lead to anaemia. In addition, the long-term use of rheumatological drugs may affect the absorption and metabolism of nutrients.
The effect of anaemia on patients living with RA (i) Increased condition Anaemia causes a lack of oxygen in the patient ‘ s body, increases symptoms such as joint pain, fatigue, and affects the quality of life of patients. At the same time, anaemia also increases the heart burden, resulting in impaired heart function. (ii) Impacts on treatment effectiveness. Anaemia affects the efficacy of drugs and makes treatment less effective. Anaemia, for example, reduces the efficacy of anti-Rheumatism drugs and increases their adverse effects. (iii) Increased risk of complications Anemia reduces the immune capacity of patients and increases the risk of complications such as infection. In addition, anaemia affects patients ‘ mental health and causes emotional problems such as depression.
iii. Diagnosis and treatment of RA anaemia (i) Diagnosis of RA anaemia is mainly based on blood protocol, iron metabolic indicators, sero-eprotein, vitamin B12 etc. At the same time, there is a need for a combination of clinical behaviour, joint symptoms, etc. (ii) Treatment The key to treating RA anaemia is to control inflammation and reduce the immune response. Specific measures include medication, nutritional support, etc. Drug treatment consists mainly of anti-ruine, iron and vitamin B12. Nutritional support includes a reasonable diet, supplementary nutrients, etc.
IV. CONCLUDING that RA has an important impact on the incidence of anaemia, which in turn exacerbates the condition of RA patients. Therefore, the timely diagnosis and treatment of anaemia is essential for RA patients. It is important to control the development of RAs through comprehensive treatment to improve their anaemia and improve their quality of life. In the future, further in-depth research is needed on mechanisms for the incidence of RA anaemia and more effective treatment.
