Felty syndrome (Felty syndrome) is a rare disease characterized by rheumatism, spleen and reduction of white cells, with many unique features in clinical symptoms, laboratory examinations, pathology, etc.
Clinical Symptoms: (i) Symptoms of joints. Commonly in parts of fingers, wrists, knees, etc., in the form of joint pain, swelling, rigidity and restricted activity. As the condition progresses, joint malformations gradually emerge, seriously affecting the daily lives and work of patients. For example, the swollen swollen hair of the finger joints and the semi-deposition of the palm joints, which not only affect the function of the joints, but may also cause physical disability. (ii) The spleen is spleen is one of the important features of the Ferty syndrome. The spleen is usually moderately to heavily swollen and can be touched in the abdomen. Large spleen can oppress the surrounding tissue, causing abdominal discomfort, abdominal swelling, etc. The reason for the spleen is mainly the increase of lymphocytes, slurry cells, etc. in the spleen as a result of the immune response, which affects the normal functioning of the spleen. (iii) Blood system anomalies 1. Decrease in white cells: Most patients have a decrease in white cells, with the most significant reduction in the number of neutral particles. The reduction of white cells reduces the ability of patients to resist infection and is prone to infectious diseases such as respiratory infections, skin infections, etc. The frequency of infection not only increases the physical burden of the patient, but may also lead to a deterioration of the condition. 2. Anaemia: Patients are often associated with anaemic symptoms in the form of pale, weak, dizzy, etc. The causes of anaemia are mainly due to chronic inflammation, red cell formation disorders and iron metabolic anomalies. Severe anaemia affects the quality of life and physical functioning of patients. Declining slabs: Some patients also experience a decrease in slabs, which can lead to signs of skin bruising, nose bleeding and tooth bleeding. The decrease in the slabs may be related to immunological factors, spleen abnormalities, etc.
1. White cell count: The total number of white cells is generally below normal range, and the absolute value of neutral particles is significantly reduced. This is one of the key diagnostic bases of the Ferti syndrome. Hemoglobin: Patients suffer from frequent anaemia and hemoglobin levels are below normal range. Anaemia is mostly positive-cell positive-colour anaemia. Slab count: The slab count is likely to decrease and is associated with a reduction in the slab count. 4. Rheumatist: The majority of patients are positive with the Rheumatist, suggesting immunosuppressive abnormalities. 1. Anti-nuclear antibodies: Some patients are anti-nuclear-positive, suggesting their own immune response. The testing of anti-nuclear antibodies contributes to a better understanding of the immune status of patients. 2. Anti-neutral particle cell antibodies: Anti-neutral particle cell antibodies are detectable in Felti syndrome patients, which is closely related to white cell reduction. The presence of the antibody may have been involved in the process of neutral particle cell destruction.
(i) Immunological anomalies On the basis of rheumatism arthritis, the body produces an immune response to its own organization, resulting in attacks by the immune system on the joints, spleen, etc. T-lymphocytes, for example, function abnormally, resulting in immuno-regulating imbalances, further exacerbating the inflammatory response. (ii) Inflammatory reaction. Inflammation response occurs in the areas of the patient ‘ s joints, the surrounding tissue and spleen. Increased releases of inflammatory media such as tumour causes of death, white cell media, etc. resulted in tissue damage and joint damage. At the same time, inflammatory reactions affect bone marrow blood function, leading to reduced generation of white, red, etc.
IV. Complications: (i) Infections due to the reduction of white cells and the reduced resilience of patients and their vulnerability to infectious diseases. The infection not only exacerbates the patient ‘ s condition, but may also lead to other complications, such as sepsis, infectious endocrinitis, etc. (ii) Long-term arthritis and joint malformations can lead to joint functional impairments, which seriously affect the quality of life of patients. Restrictions on joint activity, muscle atrophy, etc. further increase the physical burden on patients. (iii) Other system damage, in addition to joints, spleen and blood systems, Fetti syndrome may be exhausting and other systems such as lungs, cardiovascular systems, etc. Istrogen pneumonia, pulmonary fibrosis, cardiac vascular system, cardiac valve disease, heart disorders, etc. may occur in the lungs.
Ferti syndrome has unique clinical characteristics and pathological mechanisms. Better understanding of these characteristics is important for early diagnosis, treatment and prevention of complications. As medical research deepens, awareness of the Ferti syndrome will continue to increase, providing better medical care to patients.
