Rheumatism is a common self-immunizing disease that causes many physical and life-related problems to a large number of patients, and it is interesting to note that the disease is marked by a high incidence of femininity, for many reasons.
In terms of hormonal levels, estrogen in women plays a key role. Estrogen has complex and extensive physiological effects, which regulate the functioning of the immune system. Under normal circumstances, estrogens maintain to some extent the balance of immunity, promote appropriate activity of the immune cell and the rational production of antibodies. However, estrogens may be the trigger or aggravating factor for rheumatism at special times or when hormonal fluctuations occur in individuals. For example, during pregnancy, estrogen levels have increased significantly, at which point some pregnant women are likely to experience a change in their already stable rheumatism; and after childbirth, estrogen levels have declined sharply and the body’s immune system is prone to disruption, which has led to a significant increase in the risk of rheumatosis. In addition, female estrogens are also in a changing state during the menstruation cycle, and this cyclical fluctuations can disrupt the immune system, causing the immune cells to launch the wrong “attacks” on their own joints, which over time can easily trigger rheumatitis.
Also from the point of view of genetic susceptibility, several studies have shown that women are relatively more likely to carry certain specific sensory genes associated with rheumatism. These genes are more likely to activate disease-related mechanisms when they are stimulated by external factors that are suitable for disease, such as infection, adverse factors in the environment, etc. Although men may also carry the associated susceptibility genes, women’s bodies appear to be more sensitive to the expression of these genes and the resulting immune response, as is the case in an environment that can lead to disease, where women’s bodies are more susceptible to a chain of reactions based on their genetic influence, resulting in the immune system mistakenly treating organizations such as joints and filaments as external “enemies”, which in turn trigger inflammations and symptoms of rheumatic arthritis.
The difference in lifestyle is also a point that cannot be ignored. In modern societies, women tend to be more outward-looking than men and sometimes dress more thinly even in cold weather, so that joints are exposed for long periods of time and the probability of being affected by external adverse environmental factors, such as cold, damp and damp, increases significantly. Cold irritation tends to lead to vascular contraction around joints, affects blood circulation, hinders the nutritional supply of joints and the discharge of metabolic waste, thereby destabilizing the environment within the joints and plaguing the onset of rheumatism. Moreover, women are relatively more involved in domestic work, and long periods of bending and kneeling are more frequent, increasing the load of joints, particularly in the hand, wrist and knee parts, leading to more severe wear and wear, and more likely to induce rheumatism based on the potential anomalies in the body immune system.
Psychological factors also play an important role. Women tend to be more nuanced than men and are more susceptible to external influences and fluctuations, for example, when faced with stress at work, family conflicts, etc., women are more vulnerable to anxiety, depression, etc. Long-term negative emotions can disrupt the neuroendocrine system, causing hormonal disorders, inhibition of the immune system or abnormal swelling, and the instability of the immune system increases the likelihood of inoculation and makes rheumatism more “at home”.
In general, the high incidence of rheumatism among women is the result of a combination of factors, hormonal levels, genetic susceptibility, lifestyle and psychological factors that combine to affect women ‘ s risk of disease and are important for better prevention and early detection and intervention of rheumatitis.
