What are the principles for the reduction of hormones for persons with further impairments?

hormonal drugs, especially immunosuppressants such as cortex steroids, are one of the most commonly used treatments for the treatment of regenerative and degenerative anaemia (Aplastic Anemia, AA). Hormonal treatment usually requires a dose adjustment based on the patient ‘ s condition response, including a gradual reduction to reduce side effects and avoid a rebound. The following are the principles to be followed in reducing hormonal drugs for persons with re-impairment:1. Principles of individualization- Assessment of the condition: Before the reduction, the doctor conducts a comprehensive assessment based on the patient ‘ s condition, his or her treatment response, his or her haematological recovery and the overall condition of the patient.- Drug response: Consider the initial response of patients to hormone treatment, including the extent and speed of improvement of blood pictograms.2. The slow reduction principle- Gradual reduction: hormonal reduction should be gradual, so as to avoid a sudden stoppage, which would cause a rebound or increase.- Monitoring of blood elephants: during the reduction process, changes in blood elephants, including the count of red cells, white cells and slabs, need to be closely monitored.3. Maintaining the principle of treatment- Minimal effective dose: A minimum effective dose to stabilize the blood elephant was found and maintained for a period of time.- Long-term treatment: further impairment may require long-term treatment and hormonal reduction may take some time after the dose is sustained.4. Mitigation plans- Initial reductions: After the blood elephant stabilizes, a slow reduction can begin, usually 10-20 per cent per 1-2 week.- Follow-up adjustment: adjustment of the rate and extent of reduction in response to changes in blood elephants and patient reactions.5. The principle of avoiding a rebound- Slow detoxification: if the patient reacts well to hormone treatment, it should be reduced slowly in weeks to months until the detoxification.- Surveillance of symptoms: note to be taken of any signs of a rebound, such as fatigue, increased haemorrhage, etc.6. Managing side effects- Monitoring of side effects: In the process of reduction, monitoring of hormone-related side effects, such as increased blood sugar, osteoporosis, increased risk of infection, etc.- Treatment of the symptoms: timely treatment of the symptoms.7. Treatment cooperation- Communication between patients and patients: Doctors should fully communicate with patients about reduction plans to ensure that patients understand the importance and possible risks of reduction.- Patients are subject to the same conditions: they are subject to a reduction strictly in accordance with medical instructions and are not permitted to adjust their own doses or to stop their medications.8. Emergency preparedness- Emergency programmes: in the process of reduction, be prepared to respond to possible changes in conditions, such as emergency blood transfusions, treatment of infections, etc.ConclusionsThe reduction of hormone drugs for persons with re-disability should be based on the principles of individualization, slow reduction, maintenance of treatment, avoidance of rebound, management of side effects and cooperation in treatment. The whole process needs to be carried out under the guidance of a professional physician, and the patient ‘ s condition changes and hematological indicators are closely monitored to ensure the safety and effectiveness of treatment. Patients should maintain good communication with doctors, follow medical instructions and work together to manage diseases in order to achieve optimal treatment.