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Septicaemia is a serious whole-of-body infectious disease with complex and multifaceted causes. The following is a detailed analysis of the causes of sepsis:
I. Invasion of pathogens
The core cause of sepsis is the invasion of human blood by pathogens and their toxins, in which they breed and release toxins, thereby causing a series of serious systemic symptoms. These pathogens may come from several ways, including but not limited to:
Skin and mucous membrane breakdown: When the skin or mucous membrane is broken, such as trauma, burns, surgical cuts, etc., pathogen bacteria can easily enter the body through these wounds and enter the blood cycle.
Medically transmitted infections: In hospital settings, pathogens may enter the blood cycle as a result of various medical operations (e.g. intubation, surgery, dialysis, etc.). Medically transmitted infections are more likely to occur, especially among patients who have long-term retention of catheters, use of immunosuppressants or broad spectrum antibiotics.
Chronic infection stoves: Some chronic infections, such as chronic ear, sinus, osteoporosis, can spread to the whole body through blood circulation if treatment is not provided in a timely manner.
II. Types of pathogens
There is a wide variety of pathogens with sepsis, including bacteria, fungi, viruses, etc. Among them, bacteria are the most common pathogens, consisting mainly of:
Geran positive fungus: e.g., pneumococcus, pneumococcus, etc. These bacteria are widespread on the skin surface, in the respiratory tract and in the digestive tract, and can cause sepsis once there is an opportunity to enter the blood cycle.
Genran cactus: e.g. coli, creberella pneumonia, etc. These bacteria usually occur in the intestinal, urinary and urinary tracts and may enter the blood cycle, including through medical operations.
Oxygen: e.g. Vulnerable bacterium, digestive streptococcus, etc. These bacteria grow and reproduce in aerobic conditions and may enter the blood cycle as a result of deep trauma or surgical operations.
Bacillus: e.g., white mellitus, fungus. Fung sepsis is most prevalent among patients with low immune functions, such as chronic use of immunosuppressants, broad spectrum antibiotics or radiation treatment.
Host factor
The host factor is also an important cause of sepsis, including:
Immunological deficiencies: Immunological deficiencies due to a variety of causes, such as malnutrition, blood diseases, kidney syndromes, and the long-term use of immunosuppressants, can reduce host resistance to pathogens and thus contribute to sepsis.
Age factor: Older persons and infants are more vulnerable to sepsis because of their relatively weak immune functions.
Basic diseases such as diabetes mellitus, cirrhosis of the liver, chronic pulmonary diseases, may reduce the host ‘ s capacity to remove pathogens, thus increasing the risk of sepsis.
Other factors
In addition to the above, there are other factors that may lead to sepsis, such as:
Drug factors: The long-term use of broad-spectral antibiotics can lead to in vitro spasm disorders, resulting in a large-scale reproduction of drug-resistant bacteria, thus increasing the risk of sepsis.
Environmental factors: Environmental pollution, bad living habits, etc. may also have an impact on sepsis.
Based on the above, sepsis has many and varied causes, involving the invasion of pathogens, the type of pathogens, the host factor and many other aspects. Therefore, in the prevention and treatment of sepsis, these factors need to be considered in a comprehensive manner and targeted measures taken to reduce the risk of morbidity. Patients with sepsis should be examined as early as possible to identify the pathogen type and to select appropriate antibacterial drugs for treatment based on the results of drug sensitivity tests. Increased support for treatment and increased immunity are also important tools for the treatment of sepsis.
