It’s important to know your own period.
Membranoous Nephropathy, MN, is a pathological diagnosis, characterized by renal small ball cell substrate thickening and immunosuppression. Based on the pathological changes under the electron microscope, membrane kidney disease can be divided into three stages, and understanding of its own stages is essential for the development of treatment programmes and for pre- and post-assessment.
Periods of membrane kidney disease
1. Period I: This period was characterized by a large number of small hilly sediments on the upper skin side of the nephrocyte base membrane (GBM), which are usually small and of high electron density.
2. Phase II: During Phase II, sediments under the base membrane began to integrate into larger sediments, and the base membrane began to increase in thickness, but there was still a clear interface between the sediment and the base membrane.
3. Phase III: By Phase III, the sediment was further increased and led to a significant increase in the base membrane thickness, the interface between the sediment and the base membrane became blurred and there was a risk of a spike-thrust change in the surface of the base membrane.
To understand the importance of phasing
I. Development of treatment programmes
1. I-phase membrane renal disease: At an early stage, the structure of the kidney ball is relatively light, so it may be possible to control symptoms by means of conservative treatment, such as the use of vascular stressor converter enzyme inhibitor (ACEI) or vascular stressor II receptor (ARB), as well as the use of urea and blood resin reduction drugs.
2. Second membrane renal disease: As the condition progresses, more active treatment may be required, including the use of sugar-coated hormones and/or immunosuppressants, such as cyclophosphate, cyclothylene, etc., to reduce the sedimentation of immune compounds and to mitigate damage to the substrate.
3. Third-stage membrane kidney disease: In the late stages, treatment is more difficult because of serious damage to the substrate and may require more immunosuppressive treatment or other treatments, such as plasma replacement or kidney substitution treatment.
II. PRELIMINARY EVALUATION
1. Membrane diseases: Early detection and treatment have relatively good prognosis, with some patients likely to reverse their condition.
2. Second stage membrane renal disease: The prognosis of patients in the medium term depends on the timeliness and effectiveness of treatment and on the effective control of complications.
3. Third-stage membrane renal disease: late-stage patients have poor prognosis and high risk of kidney failure and may require long-term kidney substitution treatment.
Monitoring of treatment responses
Knowledge of their own instalments helps to monitor treatment responses. The objectives and responses of treatment may vary in different phases:
1. Phase I: Treatment may be aimed at reducing protein urine and preventing progress, and treatment response is usually faster.
2. Phase II: The treatment target includes, in addition to the reduction of protein urine, the process of mitigating the increase in the base membrane, which may take longer to show.
3. Phase III: The treatment target may be more focused on reducing the rate of deterioration of the kidney function and the treatment response may be more limited.
IV. Improved quality of life
Knowing their own instalments helps patients better manage their lives and expectations:
1. Period I: Patients may not need to change their lifestyle too much, but they need to monitor their condition regularly.
2. Phases II and III: Patients may need stricter dietary control and more medical intervention, which may have a greater impact on quality of life.
How do you know your own instalments?
1. Renal activity: The renal activity is the gold standard for determining the spectrospection of membrane kidney disease, and changes in the base membrane of the kidney ball are observed through an electronic microscope.
2. Periodic examinations: periodic urine examinations, blood tests and kidney function checks are conducted to monitor changes in the condition.
3. Specialized counselling: To maintain communication with kidney specialists and to learn about their situation and treatment programmes.
In conclusion, knowledge of the chronology of membrane kidneys is essential for patients. It not only helps doctors to develop appropriate treatment programmes, but also helps patients to better understand their condition and to cooperate actively in the treatment, thus improving the prognosis and quality of life. Therefore, patients with membrane kidneys should pay attention to regular examinations and communication with doctors to ensure that treatment programmes are consistent with the situation.
