The digestive perforation is a more severe acute abdominal condition, with perforated gastrointestinal contents entering the abdominal cavity and causing abdominal infection, so that a reasonable choice of antibacterial drugs is essential.
First, the choice of antibacterial drugs is based on the knowledge of common pathogens of diabolical perforation of abdominal infections. There is a large number of bacteria in the digestive tract, the most common pathogens after perforation, including gland cactus, e.g., e.g., coli, mutated bacterium, etc., which form part of a normal intestinal fungus. At the same time, gland positive bacteria such as streptococcus, intestinal fungi etc., and anaerobic bacteria such as VFC are also involved in the infection process. This is because anaerobic conditions within the abdominal cavity facilitate the growth and reproduction of anaerobic bacteria and a certain amount of anaerobic bacteria is inherent in the gastrointestinal tract.
I. Types and characteristics of commonly used antibacterial drugs
1. Beta – intraamide/beta – intraamide inhibitor compound
– Like the Amosilin-Clavic acid, where the Amosilin is a wide spectrum of beta-nimide antibiotics that can inhibit the synthesis of bacterial cell walls and can be effective for many Grelan positives and some Grelanes. Clawic acid, which is a beta-nimide enzyme inhibitor, protects Amocrine from the bacterial hydrolysis of β-nemamase, thereby expanding the antibacterial spectrum and enhancing antibacterial activity. This compound is effective for possible combinations of infections, including bacterial infections with enzymes, after perforation.
– He’s a common combination of drugs. Xeroxilin has a powerful antibacterial effect on the gerranes, and he Zerbathan is able to suppress a wide range of β-nimaminease. It has a good permeability in the abdominal tissue and is effective in the suppression of pathogens in the abdominal, especially those infections that have a significant effect on the cortex and VFFC.
Carbon cyanide
– Amphetamine Penan-Histratin is a typical carbon-cyanide drug. Alhamphetamine has a very broad antibacterial spectrum and has a strong fungicide for the Geran positives, the granics and the anaerobics. It can inhibit methamphetamine metabolism in the kidneys and increase its internal stability. In cases of acute abdominal infections caused by perforation, especially for patients who may be at risk of drug-resistant infections, such as long-term antibiotics or in-hospital digestive perforation, carbon cortex is able to control the infection quickly.
– The antibacterial spectra in the United States of America is similar to that in the case of amphetamine, but it may be more advantageous in terms of drug safety, for example, because of its relatively low probability of causing adverse reactions to the central nervous system, such as epilepsy. It can penetrate the bacterial cell wall, combines it with the bacteria’ penicillin and inhibits the synthesis of bacteria’ cell walls for the purpose of microbicide.
3. Nitromazole
– Metrazine is a highly selective antibacterial drug for anaerobics. It can cause bacterial deaths by dissecting or preventing the synthesis of bacterial cell DNA spiral structures. In the treatment of indigestion perforation, it is used mainly to counter anaerobic infections in the abdominal cavity, where the aerobic bacteria occupy an important place in the complication. Metrazine is usually used in combination with other anti-glucella and glupositive drugs to achieve full coverage of pathogens.
– The antibacterial activity of nitrophotamine is similar to that of mitazine, but its pharmaceutical metabolic dynamics differ, for example, because its plasma half-life may be longer, which means that the interval between the use of the drug may be appropriately prolonged, although the specific use needs to be determined on a patient ‘ s basis.
Considerations for the selection of antibacterial drugs
Incidence of infection
– For simple, smaller digestive perforation, a relatively narrow range of antibacterial drugs, such as β-indomide/beta-indomide inhibitor combinations, may be selected if the infection is mild and no serious peritonealitis, etc. However, if a serious digestive perforation gives rise to serious complications such as peritoneal peritonealitis, sepsis and so forth, a strong, wide range of antibacterial drugs, such as carbon cyanide, are required.
Results of pathogen tests
– If it is possible to determine pathogen types and drug-sensitive results by means of abdominal perforation or blood culture, then the most sensitive antibacterial drugs should be selected on the basis of drug-sensitive tests. However, in practice clinical work, there are times when empirical antibacterial treatment needs to be initiated before the results are produced, when selection is based on common pathogens.
3. Individual cases of patients
– The age of the patient, the underlying illness and the function of the liver and kidney need to be taken into account. For example, the reduction in liver and kidney function of older patients may require adjustments in the dose of antibacterial drugs; for patients with an allergy history of penicillin, there is a need to avoid the use of β-neamide and to choose other appropriate alternatives.
The choice of digestive perforated antibacterial drugs requires a combination of levels of infection, pathogen conditions and individual factors of the patient, and, in its use, close observation of the patient ‘ s response and timely adjustment of treatment programmes to ensure the effectiveness and safety of treatment.
