Breast cancer treatment – EndocrineWhat’s endocrinology? Endocrine treatments have specific effects on specific tissues or cells (becoming target tissues or target cells) by influencing endocrine cell-generated hormones. hormonal receptor ER and/or PR-positive breast cancer patients recommend endocrine treatment. Endocrine treatment inhibits hormone-dependent tumour cells and reduces the tumor. Reduce or eliminate estrogen levels in the body and inhibit breast cancer cell growth. Endocrine treatment is essential in the treatment of breast cancer, which has a long history and is given greater importance because it reduces the re-emergence of hormonal-sensitive breast cancer patients and the risk of diversion from distant places. In recent years, as research on breast cancer has intensified, the endocrinology treatment has gradually been transformed from early ovarian, adrenal and perinatal surgery to estrogen receptor stressor, aromatic enzyme inhibitor, etc., and has brought the endocrine treatment of breast cancer to a new stage. Hormonal receptor-positive breast cancer is the most common breast cancer type worldwide. Sixty-five per cent – 75 per cent of breast cancer patients are estrogen-positive (ER+) and/or pregnant hormone-positive (PR+).Common endocrine drugs include:Resistent estrogen receptor medication: prevent estrogen receptor effects on tumour cell growth. Women can apply it before and after menopause. The drug falls into two categories:
1. Selective estrogen receptor regulaters (SERMs, mainly Moxiphine, Toremiven)
2. Selective estrogen receptor downwards (SERDs, mainly fluoride)
Aromatic enzyme inhibitor medication: Females after menopause are treated by preventing male hormones from being transformed into estrogens and thus not affected by estrogens from ovarians.On behalf of drugs: Anatratole, Latila, Iximetanovarian functional inhibitor: permanent deterrent to ovarian hormones. Through LHRH (yellow hormone release hormonal) agonists to treat the recurrence of breast cancer. For pre-menopausal women.On behalf of drugs: Goserrin, proprinThe ovarian surgery.Stop ovarian hormones permanently. Usually both ovaries are removed and referred to as double ovaries.Endocrine treatment has a number of concerns that require our attention. 1. Replacement of injection areas: avoid repeated injections at the same location, so as to avoid hard knots in the injection area, which affect drug absorption and cause local pain. 2. Non-interruptible: at least five years, on medical advice, without exceptional circumstances. 3. In the event of a serious drug response or a review of the progress of the tumour during the treatment, timely medical attention should be provided. 4. Prevention of osteoporosis and fracture: Endocrine treatment reduces the estrogen levels of patients and requires appropriate calcium and vitamin D to prevent osteoporosis and fractures effectively. 5. Periodic measurement of bone density: periodic measurement of bone density to assess the extent of bone injury of patients and thus to develop treatment programmes. Optical osteoporosis drugs are selected to varying degrees, and calcium reduction, etc., can be used to prevent bone loss.
