Treatment of chronic gastroenteritis antibacterials
I. Overview of chronic stomach disease and the context for antibacterial treatment
Chronic stomach inflammation is a chronic inflammation caused by the chronic irritation of stomach mucous membranes by various factors. The complications of the disease include the infection of the fungus (Hp), self-immunisation, and the retorture of the 12-finger intestines, among which Hp infection is one of the most important causes. According to statistics, about 60% – 90% of chronic stomach disease patients have Hp infections. The Hp, by virtue of its spiral structure and special viability, is fertilized on the surface and in the mucous layer of the gastric mucous membrane, producing various enzymes and toxins such as urea enzymes, disrupting the barrier function of the gastric mucous membrane, causing inflammation, long-term effects that can lead to changes in the stomach mucous membrane, intestinal life, etc. and increase the risk of stomach cancer. As a result, anti-bacterial treatment for Hp infections plays a key role in the treatment of chronic stomach disease.
Options and rationale for antibacterial treatment
(i) Classic triple therapy
In the past, three combinations of proton pump inhibitor (PPI) or americant combined two antibiotics were commonly used. For example, the combinations of Omera, Amosilin and Kracin. PPI suppresses gastric acidity and increases PH in the stomach to make antibiotics work better. Amosilin kills bacteria by inhibiting the synthesis of bacterial cell walls, while Kracin acts on bacteria’ nuclei, inhibits protein synthesis, and the synergy between the two works against Hp as antibacterial. However, with the increase in Hp resistance, the eradication rate of classic triple therapy has declined.
(ii) Pentachlor tetratherapy
At present, the main recommended programme is the Quadroxin. It’s an antibiotic. Americium acetate, such as potassium acetate, is able to form a condensate consisting of aluminum salts and slime under the effect of gastric acid, which is covered by the stomach mucous membrane surface, protecting the gastric mucous membrane from gastric acids and Hp toxins on the one hand and directly inhibiting Hp on the other. Common combinations of antibiotics include Amosilin + Cractrocin, Amosilin + Furanketone, etc. Fufuraqualone has a more fungic effect on Hp, which can disrupt bacteria ‘ oxidation processes and inhibit bacteria ‘ growth and reproduction. This four-pronged therapy has increased Hp eradication rates through a variety of mechanisms.
(iii) Individualized treatment programmes
For patients with an allergy history of penicillin, it is not possible to use Amorim. At this point, alternatives such as tetracycline and mitazole may be selected. If the patient is resistant to clacin, you can choose left oxidoxen salsa, etc. Individualized treatment programmes need to take into account, inter alia, patient history, drug allergies, local Hp resistance.
III. Points for attention in treatment of antibacterial drugs
(i) Strict application of medication
Both Triad and Triad treatments require patients to comply strictly with their medical prescriptions and to take their medications in accordance with the prescribed treatment. The general americium Quadroxin treatment is 10 – 14 days. Inadequate treatment may lead to incomplete Hp removal, increasing the risk of relapse and the likelihood of drug resistance.
(ii) Concern about the adverse effects of drugs
Antibacterial drugs may cause multiple adverse effects. For example, the Amosilin can cause allergies, manifested in rashes, itchings, etc.; carcinophene can lead to gastrointestinal discomfort such as oral pain, nausea, abdominal pain; americ acid can make gourmet black, and long-term or large-scale use may pose a risk of thorium poisoning; and americ acid can give rise to oral aroma, neurological symptoms such as headache, dizziness, etc. If the patient suffers from abnormal symptoms during his/her medication, he/she shall inform the doctor in due course.
(iii) Food and living habits
During antibacterial treatment, patients maintain good diet and living habits. The diet is light, digestive and avoids the consumption of spicy, greasy and irritating foods that can stimulate gastric mucous membranes, increase stomach discomfort and affect drug efficacy. At the same time, there is a need to regularize, to avoid staying up late, to stop smoking and drinking and to reduce the adverse irritation of gastric mucous membranes.
Post-treatment assessment and follow-up
(i) Review Hp
After the antibacterial treatment has ended, a review is usually required at least four weeks after the withdrawal. The usual means of review is carbon – 13 or carbon – 14 exhale. If the results of the review indicate that Hp is still positive, the reasons for this need to be further analysed, possibly in cases of unreasonable treatment, poor patient dependence or re-infection.
(ii) Permanent follow-up visits
Long-term follow-up is required for chronic stomach diseases, especially those associated with atrophy of the stomach mucous membrane, intestinal organisms and so forth, even if Hp is successful. The changes in the gastric mucous membranes are observed through regular gastroscopy and pathology examinations in order to detect, in a timely manner, possible pathologies, such as early stomach cancer, and to provide appropriate treatment.
In short, anti-bacterial treatment for chronic stomach disease is a systematic and complex process, requiring a doctor to develop a reasonable treatment based on the patient ‘ s specific circumstances and the patient ‘ s active cooperation in order to increase the Hp eradication rate, improve the prognosis of chronic stomach disease and protect the patient ‘ s stomach health.
