Wang Xiaobin, a medical physician at the county hospital
I. Clinical applications
(i) Treatment of gland cactus infections. Amino-succus antibacterial drugs have a strong antibacterial activity for multiple gland cactus. For example, in the treatment of bacterial infections in the intestinal bacterium, it is shown to be positive, as in the case of the intestinal eschew, creber, etc. For these bacteria-induced urin system infections, amino-sugar-type drugs can effectively inhibit bacterial growth, relieve symptoms such as urination frequency, urinary acuteness and urinary pain and contribute to the reduction of inflammation. In the case of abdominal infections, this type of drug can be used in conjunction with other suitable antibacterial drugs to control the infection and reduce the risk of serious complications such as sepsis when it is contaminated with the abdominal cavity due to, inter alia, intestinal perforation.
(ii) Treatment of gland positive bacterial infections. Although amino sugar slurry is primarily directed at glandella, it also has some effect on some gland positive bacteria. Amino sugar slurry can enhance antibacterial effects when it is used in combination with other anti-gland positive fungi infections, especially the methoxysilin-resistence gold and yellow fungi (MRSA).
(iii) Treatment of Bronze Brethren Brethren Brethren, a common hospital with greater resistance to STDs. Tebcocin and tycocin, among the aminomal glucose antibacterials, have better antibacterial activity for copper-greens. In the treatment of lung and burn-faced infections caused by the copper-green cystasy, as part of the joint treatment programme, the ability to clean up this persistent pathogens can be improved.
(iv) Application in exceptional circumstances. Some serious systemic infections, such as sepsis, infectious endocrinitis, can be used in conjunction with other antibacterials that have synergies when the pathogens are sensitive to the aminomal sugar type. This combination of drugs can rapidly reduce the bacterial load in blood and quickly improve the patient ‘ s condition.
Attention and adverse reactions
(i) Ear toxicity
This is one of the most serious adverse effects of amino sugar. Ear toxicity can be classified as pre-court functional impairment and snail nerve damage. The damage to the function of the front court is manifested in dizziness, nausea, vomiting, eye tremors and balance disorder, and the patient may be in a state of uncertainty. Hearing impairments, which can lead to loss of hearing or deafness, are often irreversible. Thus, in the course of their use, close observation is made of whether the patient suffers from ear-related disorders.
(ii) Renal toxicity
Amino sugar can cause kidney toxicity, mainly in the form of protein urine, tube urine, blood urine, etc., and can lead to a reduction in kidney function in serious cases. The drug accumulates within the cortex of the kidneys and affects the normal functioning of the kidneys. The kidney function, including indicators such as blood acetic anhydride, urea nitrogen, etc., needs to be monitored on a regular basis during drug use. If an abnormal kidney function is detected, the dose should be adjusted in a timely manner or the drug should be discontinued. In the case of patients with incomplete kidneys, this type of drug is used in a way that adjusts the programme to the kidney function or chooses other alternatives.
(iii) Nerve muscle paralysis
Amino-glucose-like drugs can be combined with calcium in the mimic, thus preventing the release of acetylcholine and causing neuromuscular paralysis. This is more likely to occur at large doses of intravenous injections or abdominal administration, which can be seen in muscle insufficiency, difficulty of breathing, etc. In case of neuromuscular paralysis, intravenous calcifiers (e.g., calcium glucose) should be immediately rescued. At the same time, in the use of drugs such as anaesthesia, muscle relaxants and other substances that may affect the functioning of the nervous muscles, care is taken to combine them with amino-sugar-type drugs in order to prevent an increased risk of neuromuscular paralysis.
(iv) Allergies
Some patients may be allergic to amino-sugar-type drugs, with symptoms such as rash, fever, acidic cell increase and acute shock. Before they are used, they are asked in detail about patients ‘ allergies and should be avoided for patients with allergies. In the event of an allergic reaction during the course of the drug use, the drug should be discontinued and the corresponding anti-allergy treatment provided.
(v) Drug interaction
The risk of adverse reactions increases when carbamate-type drugs are shared with other renal and ear-toxic substances, while co-locating with urea can also increase ear toxicity. These interactions should be fully taken into account in the joint use of drugs, so as to minimize the occurrence of adverse drug interactions. In addition, there may be co-infective antibacterial effects when used in combination with β-nimamine.
Based on the above, amino-clucose antibacterial drugs play an important role in clinical anti-infection treatment, and because of their high and severe adverse effects, adaptation certificates, dosages and treatment procedures must be strictly in place to ensure their safety.
