Clocin-like drugs have been important in the field of anti-infection treatment and, although their use is limited today, they still work in specific situations. Understanding the amount of use used and the care required are essential for rational use.
Usage
(i) Oral administration; For bacterial meningitis and encephalophages, the adult dose can be increased to 50 mg/kg per day, in four doses; the child dose is similar to that of an adult on a body weight basis, subject to appropriate adjustments to the condition and age, and the newborn is used with caution. In the oral use of chlorocin, it is advisable to take it after the meal in order to reduce the irritation of the gastrointestinal tract.
(ii) An intravenous drip can be used when serious infections require rapid effects. When chlorocin injection fluids are used, the drug is generally diluted in a suitable 5% glucose injection or sodium chloride injection. The adult dose is usually 2-3g per day, with 2 intravenous drops; and the child dose is 30 – 50 mg/kg per day, with 2 – 3 drops per day. It is not appropriate to be too fast to cause adverse reactions, while being mindful of the taboos of drug ration.
(iii) Local drugs. Chlorocinide drip eye fluids are often used for eye infections such as trachoma, coronitis, etc. Usually one or two drops of each, once every two hours, or as prescribed by the doctor. Clocin ointment is painted on the eyelids with appropriate pre-sleep levels. Chloroxin drips are used for ear infections at 2 – 3 drops per ear, 3 times per day. 1. The effects of chlorocin on the blood system are one of the most serious adverse effects. It can lead to a reduction in reversible blood cells, in the form of a decrease in white cells, a decrease in blood plate, etc., most of which occur during long-term or large-dose use. There is a high risk of regenerative obstructive anaemia, which, although low in incidence, is less likely to occur. Blood routines are regularly checked during use and should be stopped in a timely manner if abnormal blood cell counts are detected. The grey baby syndrome, which occurs mainly in newborns and premature babies. Due to the underdeveloped liver enzyme system of newborns and premature babies, poor kidney excretion and the accumulation of chloroacin in the body, symptoms such as abdominal swelling, vomiting, sexual palsy, micro-circulatory disorders, invertebrates and irregular breathing can endanger life. Neonatal and premature births should therefore be avoided, and if necessary, dosages should be strictly controlled and blood concentrations closely monitored. 3. Gastrointestinal reaction. Oral chlorin can cause gastrointestinal discomfort such as nausea, vomiting, appetite and diarrhoea. The adjustment of the diet to keep it light and digestive can alleviate symptoms to some extent. If symptoms seriously affect food and nutritional intake, consideration should be given to adjusting treatment programmes. 4. Allergies may also occur, such as rashes and vascular neuroema. In the case of allergies such as skin itching and red spots, the medication should be discontinued and allergy treated. Patients with an allergy should inform the doctor before using them.
(ii) Drug interactions Chlorin inhibits the activity of certain hepatoparticle enzymes, thus affecting metabolism of other drugs. For example, it enhances the role of anticondensers such as Wafalin and increases the risk of haemorrhage; co-use with sodium benzo-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p-p- Therefore, in the case of chlorcin, the patient should inform the doctor of the other drugs that are being used and the doctor needs to assess the possibilities of the drug interaction in a comprehensive manner.
(iii) Use of specific population groups 1. Pregnant and lactating women For breastfeeding purposes, chlorocin may enter the milk in small quantities, which may affect the infant and should be carefully used or suspended. 2. Older persons 2. The liver and kidney function of older persons may decline and are more vulnerable to adverse effects when using chlorcin, requiring careful use and appropriate dose adjustments and enhanced monitoring.
In short, the use of chlorcin is subject to strict medical advice and trade-offs. Medical personnel and patients need to be fully informed about their use and care to ensure safe and effective use. Where safer and effective alternatives are available, priority should be given to their use.
