Anaerobic infections are an infectious disease caused by anaerobic bacteria, and because of the variety of anaerobic strains and the diversity of areas of infection, drug treatment requires the choice of appropriate drugs on a case-by-case basis.
i. Nitromium-type drugs • Metrazine: Metrazine is a common drug for anaerobic infections. It has a powerful fungicide effect on most anaerobic bacteria, such as fragile bacterium and sprouts. The mechanism of action is that the nitro of the acetazine is reduced to anaerobic bacteria in an anaerobic environment, which produces cytotoxic substances that fractures or prevents the synthesis of the bacterial DNA spiral structure and thus acts as an antibacterial function. In the treatment of oral anaerobic infections, such as dental and coronary inflammation, oral administration is generally used at a dose of 0.6 – 1.2 g per day and 3 times per day. For serious anaerobic infections such as abdominal infections, pelvic infections, etc., the drug can be injected through an intravenous drip, with a first dose of 15 mg/kg and a maintenance dose of 7.5 mg/kg every 6 – 8 hours. The use of mitazole can be characterized by gastrointestinal reactions such as nausea, vomiting and appetite, as well as neurological symptoms such as headaches and dizziness. In addition, drinking can have a double-sulphine reaction, so it should be avoided during the use of the drug. • Nitrazine: The antibacterial spectra for nitraz is similar to that of mitraz, but is more active and has a longer half-life in the body and a relatively low number of doses. For anaerobic infections, such as sepsis, osteoporosis, etc., the first daily dose is typically 2g, followed by 1g per day with 1 – 2 intravenous drips. 1 – 2 g/day for oral administration. The adverse effects are similar to but relatively light to the acetate.
ii. Carbon methacne • Aminopentamide – Westside: This is a cotrimoxant, which is an antibiotic carbon methacne, has a wide range of antibacterial activity and has a strong antibacterial effect on various bacteria, including anaerobics. As an adrenal dehydrogenase inhibitor, it reduces the metabolism in the kidneys of amphetamine, thereby increasing its stability and antibacterial activity in the body. The drug is used mainly to treat serious co-infections, which include anaerobic infections such as complex abdominal infections, lung infections, etc. Depending on the severity of the infection, the dose was generally 1 – 2g per day with 3 – 4 intravenous drops. Gastrointestinal responses such as nausea, vomiting and diarrhoea may occur during use, as well as allergies such as rashes, itching, etc., and can lead to herb-comb disorders and drug-resistant bacteria due to its extensive antibacterial spectrum. • American: Americanan also has a strong anti-aerobic capacity and has better antibacterial activity for some drug-resistant bacteria. It can quickly penetrate the bacterial cell wall, combines with the bacteria’ penicillin, and inhibits the synthesis of bacteria’ cell walls for the purpose of microbicide. There is a unique advantage in treating central nervous system anaerobic infections, such as cerebral abscess, as it is better able to achieve effective antibacterial concentrations in cerebral spinal fluids through the blood-brain barrier. The general dose was 0.5 – 2g per day with 3 – 4 intravenous drips. The adverse effects include gastrointestinal reactions, allergies and symptoms of the central nervous system, such as epilepsy, which require close observation when used.
iii. Beta – intraamide/beta – intraamide inhibitor compound • Amosilin-Clavic acid: Amosilin is a semi-synthetic penicillin that has a wide spectrum of antibacterial activity but is susceptible to hydrolysis by the bacterial beta-neamide enzymes and loss of antibacterial effects. Clavic acid is an β-Imamase inhibitor, which is used in conjunction with Amosicillin and protects it from enzyme enzyme, while expanding the antibacterial spectrum and enhancing antibacterial resistance to anaerobic bacteria. The oral dose was 0.5 – 1g (in Amosicillin) per day, 3 – 4 times per day for the treatment of infections in the oral, ear, nose and throat sections. Its adverse effects are mainly gastrointestinal and allergic. • Zolasilin – He Zolasilin is a broad spectrum semi-synthetic penicillin, and he Zarasilin is a beta-neamide inhibitor. The compound has significant antibacterial activity for a wide range of anaerobic bacteria, including e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., e.g., p. For the treatment of complex infections such as abdominal infections and skin soft tissue infections, the dose is typically 3.375 – 16.5g per day (in Zaracillin) at 3 – 4 times an intravenous drip, depending on the severity of the condition. Negative effects include allergies, gastrointestinal responses, etc. In the treatment of anaerobic infections, anaerobic culture and drug-sensitization tests are conducted to the extent possible to select the most effective drug. At the same time, attention should be paid to the dose of the drug, the course of treatment and possible adverse reactions to ensure the effectiveness and safety of treatment.
