Laparoscopic Cholecystectomy, LC, is a common and effective procedure for cholesterol diseases. Compared to traditional open surgery, the LC has the advantage of small trauma, high recovery and short hospitalization. However, post-operative pain remains one of the major factors affecting the comfort and rehabilitation process of patients. Optimizing post-operative pain and pain strategies is therefore essential to increase patient satisfaction and accelerate recovery. 1. The main source of post-operative pain is the following: 2. Inner laundrum pain: The binding of the gall bladder and its surrounding structures in the operation may cause internal infestation. Gas inflatation pain: The CO2 abdominal can cause acoustic irritation and radioactive pain on the shoulder, which is a form of pain specific to the LC. Inflammatory response: The post-operative local inflammation response also leads to increased pain. In order to effectively control post-LC pain, multi-modal pain (Multimodal Analgesia), i.e., a combination of drugs and technologies from different mechanisms of action to reduce single dose and at the same time reduce the risk of adverse reaction, is commonly used in the clinical context. The commonly used pain-alleviation methods include, but are not limited to, inflammation drugs (NSAIDs), such as Brophine, ketonic acid, which can reduce pain caused by inflammation reactions and help reduce the use of opioids. Local anaesthesia techniques, such as local insemination of the incision or neurotic retardation, can directly affect the path of pain transmission and provide good initial pain relief. (a) Vigilante self-control pain (PCA): By giving the patient a certain degree of autonomy and control, he/she can adjust the dose of the drug to his/her own pain, so that he/she can experience it satisfactorily. Extradural analgesics: For patients requiring more effective analgesics in certain specific situations, the choice is made between epidural anaesthetics or opioids. Auxiliary drugs: for treatment of psychotic rational pains, such as Gabahedine, Prishtine, etc.; sugary cortex hormones, such as Disemysson, can reduce inflammation and oedema. In addition to the above-mentioned conventional measures, individual differences, such as age, gender, syndrome, etc., need to be taken into account in the formulation of the LC post-operative pain relief programme. Older persons are often more sensitive to the side effects of opioids, such as respiratory inhibition, constipation, etc., while patients with cardiovascular diseases should carefully select painkillers that can cause blood pressure fluctuations. In addition, for patients with chronic pain or long-term painkillers, the strategy for analgesic surgery needs to be tailored. With the development of medical science and technology, new techniques and concepts of pain and pain, such as accurate neurotic retardation under ultrasound, microinvolved therapy, etc., have emerged, providing additional possibilities for post-LC pain and suffering. At the same time, the application of models based on big data analysis and artificial intelligence algorithm predictions will further enhance the accuracy and effectiveness of individualized pain relief programmes. In general, the continued exploration and improvement of post-operative pain and suffering methods of the LC will not only help to improve the quality of life of patients after surgery, but will also be an important manifestation of the fine-tuning of surgical management. Based on the above, the LC post-operative pain is a complex and detailed process involving a combination of factors. Through a rational choice and combination of different types of pain and suffering methods, we can provide safe and effective pain and relief support to every patient who accepts LC, facilitate its rapid recovery and reduce the occurrence of complications.
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