At first, Parkinson’s patients chose to take medication to control motor symptoms such as tremors and rigidity. During the time of taking the medicine, it worked very well, and the motor function almost recovered to the same level as the normal person, who could not even be seen as suffering from Parkinson’s disease. This is called a “honeymoon period” for drugs, which generally lasts three to five years. As the disease progresses, the efficacy of the drug will decline slowly or will only be achieved by a higher dose, indicating that the “honeymoon period” will end.
At the same time, there is a “switching” phenomenon, in which the patient takes his or her medication, which lasts for a shorter period of time, with a relatively longer period of time for which he or she is not effective, that is, a shorter period for so-called “opening” and a longer period for “turning off”. For example, once a drug is taken, it lasts three hours, while now it lasts only one hour. The drug most commonly used to treat Parkinson is a left-turned doba-type drug, with common side effects and anisopathia, i.e., when a patient takes a drug, his hands and feet move by his/her own accord, and he/she dances with his/her hands and feet, to a large extent.
Why is it that some of the patients who take the medications are out of control or have a more reactive response, that they can take another drug and that others will then have to install a pacemaker? How do you know if the drugs really don’t work or if they have to be adjusted or changed?
The core ingredient of a left doba drug is a left doba, which can compensate for the lack of dopamine in the brain. Whatever the plant and the formulation type of the doba drug, it is eventually converted to a left doba content, with a recommended dose of 800 mg per day. If more than 800 mg, there are potential side effects.
If the patient had previously taken other types of drugs, without the content of a left doba, the doctor would recommend that the patient switch to a drug containing a left doba ingredient when the drug is not working well or has greater side effects.
Does Parkinson’s patient have to have a brain pacemaker to control his condition?
If the definitive diagnosis is Parkinson’s disease and it has developed in the medium term, then the “honeymoon” period is just over, the “switching phenomenon” and the “isoactivity” are gradually emerging, with the optimal effect of having a brain starter. But it does not mean that all patients have to be dressed, after all, taking into account financial factors and physical affordability. The results of current research, both at home and abroad, as well as the various guides, suggest that the best time for Parkinson’s patients to install a cerebral pacemaker is when the “honeymoon season” is just over, when the “switch phenomenon” and the side effects of anisopathic drugs are just emerging.
The early installation of a pacemaker will improve the quality of life and avoid complications. However, if a rigorous assessment is required, the patient has been diagnosed with Parkinson’s disease.
So what we’re advocating is that we give the right treatment at the right time, and not wait until the drugs are completely out of hand to consider the installation of a pacemaker. Optimistic timing is the best way to achieve synergy between drugs and surgery.
