Acute pancreasitis is an inflammatory disease caused by the abnormal activation of the pancreas in the pancreas, and its clinical performance may vary from mild abdominal pain and edema to severe can lead to haemorrhage, re-infection and multi-organ function failure. In the treatment of acute pancreas, the choice and application of antibiotics is crucial, not only for the control of the condition, but also directly for the patient ‘ s prognosis. The selection strategy for antibiotics in acute pancreas is discussed in detail and the scientific basis behind it.
I. Antibiotic use principles for acute pancreas disease
Antibiotic use of acute pancreas is governed by certain principles, including the following: Insulin-infected fungi are mainly intestine-dwelling bacteria such as grenacella and anaerobics, and should therefore be covered by the choice of antibiotics. Decline treatment strategy: In the treatment of acute pancreas, broad-spectrum, strong antibiotics, such as carbon pyroacne, should be selected to control the infection quickly, and the antibiotic programme, known as the “grader” treatment strategy, should be adapted to pathogen tests. 3. Reasonable treatment: The course of treatment for antibiotics is usually 7 to 14 days, with an appropriate extension of exceptional circumstances, but should avoid unnecessary long-term use to reduce resistance.
II. Types of antibiotics commonly used in acute pancreas
Carbon cyanide: Carbon cyanide antibiotics, such as amphibian stalbutamide, which have broad antibacterial spectrometry, high antibacterial activity and stability of β-implamide, are among the most selected antibiotics for acute pancreas. It can rapidly control infections and reduce disease and death rates, but it needs to be aware of their potential kidney and neurotoxicity. 2. Head bacterium: Antibiotics of the head bacterium, e.g., cortex pine, cortex, etc., have a better antibacterial effect on the guerlan cactus and part of the gerang positive. In the treatment of acute pancreas, the antibiotics of the aphrodisiac form are commonly used as a sub-pharmaceutical for patients who are not sensitive to or resistant to carbon pyroacne. 3. quinone type: Antibiotics of quinone, such as the left oxen fluorine, have broad antibacterial spectrometry, high tissue penetration and low adverse effects. In the treatment of acute pancreas, quinone-like antibiotics are usually used in conjunction with anti-aerobic drugs to cover more fungi. 4. Penicillin+beta-neamide inhibitor: a combination formulation of penicillin antibiotics and β-neamide inhibitors, such as ammonium sicillin Shubatan, can increase the stability of penicillin antibiotics to beta-neamide enzymes and thus expand their antibacterial spectrum. In the treatment of acute pancreas, such drugs are usually one of the options.
Attention to acute pancreas antibiotic use
1. Avoiding the use of preventive medicines: Numerous clinical studies have shown that the preventive application of antibiotics to non-coalgenic acute pancreas does not significantly reduce morbidity. Therefore, the preventive use of antibiotics is not recommended for such patients. Antibiotics should be routinely used in cases of low-intensity acute pancreas or moderate and severe acute pancreas with infection. Attention to pathogen screening: In the treatment of acute pancreas, pathogen screening is an important basis for guiding the choice of antibiotics. Through the development of specimens such as blood, urine, abdominal water and drug-sensitive trials, it is possible to identify the type of fungi and the drug-sensitive, so as to select the appropriate antibiotics. 3. Attention to drug interaction: People with acute pancreas usually need to use multiple drugs at the same time, such as acids, enzymes, painkillers, etc. When using antibiotics, attention needs to be paid to the interaction of drugs to avoid adverse reactions. 4. Individualized treatment: The individual differences in acute pancreas are such that individualized treatment is required in the choice of antibiotics. Depending on the age, sex, liver and kidney function of the patient, and the severity of the condition, appropriate antibiotics and doses are selected.
Outlook for acute pancreas antibiotic treatment
The antibiotic treatment of acute pancreas will become more precise and individualized as medical technology advances and clinical research advances. In the future, technical means such as genetic sequencing and bioinformatics analysis can guide the choice and use of antibiotics by identifying more accurately the type of fungi and drug sensitivity. In addition, the development and application of new antibiotics will provide more options for the treatment of acute pancreas.
The final sentence of acute pancreas antibiotic treatment is a complex and important process. In the selection of antibiotics, a combination of the severity of the condition, the type of infection, the type of bacteria that causes it and the sensitivity of the drug is required, in accordance with the stairwell treatment strategy, with a reasonable selection of the type and dose of antibiotics. At the same time, attention needs to be paid to the principles of drug interaction and individualized treatment in order to improve treatment effectiveness and patient prognosis. In the future, the antibiotic treatment of acute pancreas will become more precise and individualized, as medical technology advances and clinical research advances.
Acute pancreasitis
