It is a chronic inflammation disease, mainly affecting areas such as the spinal column and the hips, which causes pain, rigidity and restricted activity. Biological agents are one of the most important drugs in the field of treatment of direct spinal disease. It can play a specific role in disease-related inflammation factors, which can effectively reduce inflammation responses, mitigate symptoms and slow the progress of the disease.i. Mechanisms for the functioning of biological agents: Biological agents function primarily by targeting specific inflammatory media or cytogens. For example, tumour necrosis inhibitors can disrupt the activity of tumour necrosis, which plays a critical role in the development of a direct spinal disease, which can trigger joint rinsitis, bone damage and fibrosis and verticality of the spine. By inhibiting this factor, joint pain and swelling can be effectively reduced, the activity of the spinal column improved and new bone formation reduced and the further development of joint deformities prevented.2. Timing of use of biological agents: In the case of patients with a high direct spinal column, consideration should be given to the use of biological agents when traditional treatments (e.g., anti-inflammation drugs, traditional anti-ventilating rheumatizers) are ineffective and there are continuing high levels of disease activity, such as frequent back pains, long morning rigidities and severe effects on the quality of life, or visual examinations show rapid progress in the disease and visible damage to the spinal column or cortex bone. In addition, early use of biological agents can be made to treat patients with early and serious illnesses with adverse pre- and post-incidental factors (e.g., young morbidity, high inflammation indicators, hips, etc.) in order to better control the condition and protect the joint function.III. Methods of use of biological agents: Different types of biological agents are used differently. Some biological agents are subcutaneously injected and patients can operate at home on their own, under the supervision of a doctor, usually weekly or weekly. Innapp, for example, usually takes two injections a week. Some biological agents require intravenous infusion, which requires patients to go to the hospital for treatment under the supervision of the medical staff, with intervals ranging from weeks to months, such as the Inflisi stand alone, usually in 0, 2 and 6 weeks, and every 6 – 8 weeks thereafter. Patients must have the right dose of the drug, the place of injection, the time between injections and the rate of infusion to ensure its effectiveness and safety, as prescribed by the doctor.IV. Assessment of the efficacy of biological agents: During treatment with biological agents, there is a need for regular evaluation of the efficacy. It is generally determined by the improvement of patients ‘ subjective symptoms, such as the reduction of pain levels, the reduction of morning rigidity; and changes in objective indicators, including the decline of blood sunk, C-reaction of inflammation indicators such as protein, as well as by a visual examination of the cosmos and the spine (e.g. X-line, MRI, etc.). If there is a marked improvement in the patient ‘ s symptoms during the early stages of treatment, the indicator of inflammation is declining, indicating that biological agents are working. However, if after a period of treatment (usually three to six months) the efficacy of the treatment is not significant, the doctor may consider adjusting the treatment to replace the type of biological agent or to combine other drugs.V. Safety and care of biological agents: The overall safety of biological agents is good, but there may be some adverse reactions. Some patients may have inoculations, such as bruises, pain, itching, etc., which are generally mild and self-reducing. There are also a small number of patients who may increase the risk of infection, in particular respiratory infections, tuberculosis infections, etc., and therefore comprehensive screening for infection, including tuberculosis fungus tests, chest X-line examinations, etc., is required before the use of biological agents. In the course of treatment, if the patient is suffering from infections such as fever, cough, cough, etc., he/she should be treated in a timely manner and informed that the doctor is using biological agents. In addition, the long-term use of biological agents may include issues such as increased potential tumour risk, which is currently relatively low and related to the complexity of the disease itself and individual differences among patients. During the use of biological agents, patients should strictly follow the doctor ‘ s regular follow-up arrangements in order to detect and address possible adverse reactions in a timely manner.Biological agents bring new hope and options for treatment for people with high-relationship spina. By rationally managing its mechanisms, using its timing, using its methods, evaluating its efficacy and paying close attention to safety and care, biological agents can play a greater role in the treatment of high-relationship spina, helping patients to control their condition effectively, improve their quality of life and re-accept a healthy life.
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