Application of sacubatron and valsartan sodium in patient with heart failure

As a novel compound preparation, sacubatron and valsartan sodium tablets are synthesized by two active ingredients of sacubatron and valsartan through chemical reaction, and have the characteristics of good stability and difficult degradation. It has shown remarkable efficacy in the treatment of cardiovascular diseases, especially in the treatment of heart failure. However, patients with heart failure need to pay attention to a series of matters to ensure the safety and effectiveness of the drug. 1. Mechanism of action and indications of drugs Sacubatron Valsartan Sodium Tablets can reduce the burden of the heart and improve the heart function mainly by inhibiting the renin-angiotensin-aldosterone system (RAAS) and enhancing the action of the natriuretic peptide system. In addition, it can also block angiotensin II receptors, dilate blood vessels and lower blood pressure. These mechanisms of action make sacubatroxobin valsartan sodium tablets significantly effective in the treatment of heart failure, improving symptoms and quality of life in patients with heart failure and reducing the risk of cardiovascular death and hospitalization for heart failure. 2. Preparation and evaluation before medication Doctor’s evaluation: Before using sacubatrol valsartan sodium tablets, patients should consult a professional doctor for a comprehensive physical examination and evaluation to determine whether the drug is suitable for use. Allergic history: Patients who are allergic to sacubatron, valsartan, or any of the excipients should not use sacubatron valsartan sodium tablets to avoid allergic reactions. Special Populations: Pregnant women, lactating women, people with hepatic insufficiency, people with renal insufficiency, and children under 18 years of age should consult a physician and use with caution before using sacubatran valsartan sodium tablets. 3. Precautions during medication: Follow the medical supervision: Patients should strictly follow the doctor’s instructions, and should not increase or decrease the dosage or stop taking the medicine. Doctors will determine the dosage and medication time according to the specific conditions of patients to ensure the efficacy and safety of drugs. Regular monitoring: During the period of medication, patients need to regularly monitor blood pressure, renal function, blood potassium level and cardiac function. These monitoring can help to detect the possible side effects or adverse reactions of drugs in time, so as to adjust the treatment plan in time. Dietary adjustment: During medication, patients should maintain a balanced and regular diet and avoid eating foods with high salt, fat and sugar. These foods may increase the burden on the heart and affect the efficacy of drugs. Avoid the combination of specific drugs: sacubatro valsartan sodium tablets should be avoided with potassium supplements, potassium-sparing diuretics and other drugs to prevent the occurrence of hyperkalemia. In addition, the combination with ACEI drugs, ARB drugs, aliskiren and other drugs should be avoided in order to avoid increasing the risk of adverse reactions such as angioedema. Observation of adverse reactions: In the course of medication, patients may have dizziness, hypotension, edema, renal damage, hyperkalemia and other adverse reactions. Once these symptoms occur, they should seek medical treatment immediately and take targeted treatment measures under the guidance of doctors. 4. Lifestyle adjustment and adjuvant therapy Appropriate exercise: Patients with heart failure should choose suitable exercise methods according to their physical condition, such as walking, Tai Chi, etc. Exercise can help improve heart function, increase exercise tolerance and improve quality of life. Smoking cessation and alcohol restriction: Smoking and alcohol consumption may increase the burden on the heart and affect the efficacy of drugs. Therefore, patients with heart failure should quit smoking and limit alcohol, and maintain a healthy lifestyle. Psychological adjustment: Patients with heart failure may face greater psychological stress and anxiety. Therefore, patients should actively carry out psychological adjustment, maintain an optimistic attitude, and cooperate with the doctor’s treatment. 5. Treatment of special conditions during medication Dosage adjustment: For patients with hepatic insufficiency or renal insufficiency, the doctor may adjust the dosage according to the specific conditions of the patient. Patients should strictly follow the doctor’s instructions for medication. Drug Interactions: Patients should consult their physician and inform themselves of their medication if other medications are indicated during the use of sacubatroxobin valsartan sodium tablets. Doctors will provide reasonable medication advice to patients according to the interaction of drugs. Withdrawal and change of medication: If patients have serious adverse reactions or deterioration of their condition during medication, they should stop medication immediately and seek medical treatment. Doctors will decide whether to change other drugs or take other treatment measures according to the specific situation of patients. 6. Summary: sacubatroxobin valsartan sodium tablets play an important role in the treatment of patients with heart failure. However, in order to ensure the safety and effectiveness of medication, patients need to strictly follow the doctor’s instructions, regularly monitor the relevant indicators, avoid the combination of specific drugs, adjust diet and lifestyle, and pay attention to the occurrence of adverse reactions. At the same time, patients should also maintain a positive attitude, cooperate with the doctor’s treatment, and jointly overcome the disease. The quality of life of patients with heart failure can be significantly improved through rational medication and active lifestyle adjustment. Heart failure