Bacteria produce resistance in several ways.

Bacteria resistance, as one of the serious challenges facing modern medicine, is receiving increasing attention from all sectors of society. It refers to the relative insensitivity and resistance of bacterial antibiotics, which are not the result of a single factor but of a combination of factors. This paper will explore in depth several aspects of bacteria’ resistance, with the aim of raising public awareness of the phenomenon and calling for joint efforts to rationalize the use of antibiotics to curb the spread of bacteria’ resistance.Classification of bacterial resistanceFirst, we need to know the classification of bacterial resistance. Depending on why it occurs, resistance can be divided into inherent resistance and access to it. The inherent resistance, also known as natural resistance, is determined by the bacterial chromosomal genes and transmitted from generation to generation, and does not change. For example, streptococcus has a natural resistance to aminocyte antibiotics, intestinal glycoccus to penicillin G, etc. The acquisition of resistance is when bacteria, in contact with antibiotics, alter their own metabolic pathways by means of a particle guidance to protect them from antibiotics. This resistance can be eliminated by no longer having contact with antibiotics, and it can be transmitted from a particle to a chromosome to an inherent resistance. The mechanism by which bacteria produce resistance is complex and varied, and includes, inter alia, the following: 1. The creation of active enzymes: the bacteria can produce enzymes that are active antibiotics, which is one of the most important mechanisms for drug resistance. These enzymes can destroy the structure of antibiotics and render them sterile. For example, β-NIA can crack the β-NIA rings of penicillin and capisculin, rendering them completely sterile. 2. Changes in the target levels for drug effects: Bacteria can alter the protein structure and quantity of the target levels for antibiotics, leading to the loss of antibiotics from their effective integration with bacteria. 3. Infiltration barriers to antibacterial drugs: Changes in the cytowall and permeability of bacteria can affect the entry of antibiotics into the bacteria, thus preventing them from being antibacterial. 4. Effects on active excretion systems: Some bacteria are able to pump antibiotics into the fungi, reducing their antibiotic concentrations and thus their antibacterial effects. Other mechanisms: Bacteria can also be resistant to antibiotics through the formation of bioreceptive membranes and the increase of metabolic stress. In addition to the biological properties of the bacteria themselves, the external factors that arise from bacterial resistance play an important role in the production of bacterial resistance. Among them, the abuse of antibiotics is one of the most important external factors. Antibiotic abuse is particularly high in my country. Common influenza, inpatients and surgical patients often use antibiotics at random, and there are many patients who use more than two antibiotics. Such unregulated drug use not only does not effectively treat diseases, but may also accelerate the generation and spread of bacterial resistance. In addition, bacterial resistance is transmitted in a variety of ways. Particle transmission, hand contact by medical personnel and patient-to-patient transfer are important means of bacterial resistance. The existence of these means of transmission allows for the rapid spread of bacterial resistance in different individuals and environments. To curb the spread of bacterial resistance, we need to take a series of measures. First, the establishment of a bacterial resistance monitoring system is key. By monitoring bacterial resistance, we can keep abreast of trends in the emergence and spread of resistant bacteria and provide a scientific basis for the development of control measures. Secondly, the rational use of antibiotics is an important means of curbing bacterial resistance. We should follow the doctor ‘ s advice and use antibiotics strictly in accordance with the time and dosage of the drug to avoid abuse and misuse. At the same time, it is essential to strengthen infection control and to reduce the incidence of hospital infections. In sum, the emergence of bacterial resistance is a complex process involving multiple aspects and factors. In order to contain its spread, we need to take a multidimensional approach and take comprehensive measures. Only through joint efforts and sustained action by society as a whole will we be able to respond effectively to this challenge and protect the physical health and safety of people.