Chloroxin antibacterial drugs: use with caution and protection against risk

In the extended family of antibacterials, there has been a wide range of applications of antibacterials of chlorcin. However, with the development of medicine, there is a better understanding of its safety and use norms. Knowledge of the daily use of, and attention to, chlorcinic antibacterials is essential for rational use and health protection.I. Types and characteristics of Clocin antibioticsClocin-based antibacterials are mainly represented by chlorcin. It has broad-spectrum antibacterial effects, which inhibit the synthesis of bacterial proteins, as well as a certain antibacterial activity for a wide range of pathogens, such as typhus, typhoid fungi, haemophilus influenzae, pneumococcus, etc. In the past, many infectious diseases have been treated, including typhoid fever, typhoid fever, eye infections and ear infections.II. Oral formulations of type (i) daily use and utilisation: Clocin tablets or capsules are generally used by adults at a daily rate of 1-2 g, 3-4 times. Children are given three to four doses of 25 to 50 mg/kg bw/day by weight. For example, for a 20 kg child, the daily use was about 500 – 1000 mg and at 3 – 4 doses, about 125 – 250 mg each. Appropriately warm water delivery is used, preferably one hour before or two hours after meals, to facilitate drug absorption. Injectives: Clocin injection fluids are usually intravenous dripping or muscle injections in hospitals by medical professionals. At intravenous dripping, the daily dose for adults was in general 1-2 g, 2-4 doses for children and 25-50 mg/kg/kg/day and 2-4 drops. At the time of the injection, adults used 0.5-1 g per injection and children lost their weight at a corresponding dose. During ivulatory dripping, the drip speed is strictly controlled to avoid over-speed causing adverse reactions. Eye formulations: Clocinol drip eye fluids are often used for the treatment of eye infections, such as conjunctivitis and carnival. It usually drops 1-2 drops per drop, 3-6 times a day. They should be used first to wash their hands, then to turn their heads behind their heads, and then gently pull out of their eyelids, and drop the drop of their eyes into the lower eyelids to avoid the drop of their mouths in contact with the eyes or other parts in order to prevent contamination. Ear formulations: Chlorocinide drips can be used for the treatment of ear infections, such as ear disease, with a drop of 2-3 drops per day, three times a day. The drug should be side-stamped, subject to an earliding, and maintained in the position for a few minutes after it had been dropped, so that the drug could be fully effective at the site. (ii) The drug treatment process for the chloracinic antibacterial drug varies according to the type and severity of the infection. For mild infections, such as light eye or ear infections, the medication may be shorter, typically 3-7 days. For some of the more serious systemic infections, such as typhoid, the course of treatment is usually 10-14 days. In the course of the treatment, the doctor makes a comprehensive determination on the basis of the improvement of the patient ‘ s symptoms, the results of the laboratory examination (e.g., blood protocol, pathogen culture, etc.) as to whether it is possible to stop the drug or to extend the time of its use to prevent the recurrence of the infection or the bacteria from producing resistance.Note (i) One of the most toxic adverse effects of chlorocin in the blood system is on the blood system. It may inhibit bone marrow blood function, leading to a decrease in white cells, a decrease in blood platelets and even the regeneration of obstructive anaemia. Before the medication is used, a regular blood examination is carried out to understand the patient ‘ s basic blood. The blood routine is periodically reviewed during the use of the drug, usually at least one or two times a week. If a white cell count is found to be below normal range, the plate plate is reduced or anaemic symptoms, such as inactivity, dizziness, pale color, etc., should be stopped immediately and medically treated in a timely manner. For people with chronic drug use or family history of blood system diseases, blood indicator changes are monitored closely.(ii) The grey baby syndrome is a uniquely negative reaction of chlorocin in newborns and premature births. The metabolic and detoxification processes of chlorcin in the body are affected by the lack of glucose algebrae transfer enzymes in the liver of newborns and premature children, which leads to the accumulation of drugs in the body, causing symptoms such as circulatory failure, respiratory difficulties, reduced sexual pressure, skin paleness and hair, which can endanger life in serious cases. Newborn and premature births should therefore be banned unless there are special, critically assessed clinical conditions and very low doses are closely monitored.(iii) Patients with allergies may be allergic to chlorocin, in the form of skin allergies such as rashes, itching, vascular neurological oedema, etc., and can have an allergic shock if severe. Prior to the first use of chloropicrin, patients should be asked about their allergies, including other drugs, food, etc. In the event of an allergic reaction during the course of the drug, there should be an immediate stop and an anti-sensitization treatment, such as the use of antimontamine drugs, adrenaline and, if necessary, first aid treatment.(iv) The effects of the liver and kidney function, although the direct damage to the liver and kidney function by chloroquine is relatively small, may impose a certain burden on the liver and kidney by long-term or large-scale use. Indicators of liver and kidney function, such as serotransmase, cholesterol, acetic anhydride, urea nitrogen, etc., can be regularly monitored during use of the drug. In the case of patients with incomplete liver and kidneys, care is taken when using chlorocin, and doctors may adjust the dose or choose other alternatives to the patient ‘ s condition.(v) The interaction between the drug and some of the drugs occurs. For example, co-use with epilepsy drugs such as sodium phenyltropine may inhibit the metabolism of sodium phenyltropine, increase its blood content and increase the toxic reaction of sodium phenyltropine; co-use with oral sugar can increase the reduction of sugar and increase the risk of low blood sugar; and co-operation with anticondensive drugs such as Wafalin may increase the anticondensive effect and increase the risk of haemorrhage. Therefore, all other drugs that are being used by doctors should be informed prior to the use of chlorocin, so that doctors can assess the interaction of drugs and develop rational drug use programmes.(vi) Medication for pregnant and lactating women: Clocin can enter the foetus through a placenta barrier, with adverse effects on the foetus, such as foetal marrow inhibition, so that pregnant women should avoid its use. When breast-feeding women use chloroacin, the drug enters the milk, which may have an impact on, for example, the bone marrow blood function of the baby, so that breastfeeding should be suspended for the duration of the drug.Children: In addition to the previously mentioned ban on newborns and premature births, for other children, the use of chloropicrin-type drugs requires rigorous adaptive certificates, accurate dosage calculations and close monitoring of adverse effects, especially blood system toxicity.Older persons: The reduction in liver and kidney function of older persons, the reduction in metabolism and excretion of drugs, and the risk that adverse effects may occur when chlorcin is used, should be monitored more closely and the doctor may adjust the dose as appropriate.Chlorocinic antibacterial drugs still have application value in specific cases, but due to their potentially serious adverse effects, they must be used with the strict guidance of a doctor. In the course of their use, patients are actively involved with doctors in conducting all examinations and monitoring, and in providing timely feedback on physical discomfort so that doctors can adjust their treatment programmes in a timely manner to ensure that the medication is safe and effective.