Choice of anti-infection drugs

The choice of anti-infection drugs is a complex and critical decision-making process that requires a combination of factors to ensure the effectiveness and safety of treatment. First, it is essential to identify pathogens. Before choosing an anti-infection drug, every possible method should be used to identify the pathogens that cause the infection. This may include taking samples of the patient ‘ s blood, urine, sluice, brain spinal fluids, etc., for pathological examinations such as bacterial culture, viral testing, fungi culture and pharmacological sensitivity tests. The results of sensitive tests directly reflect the sensitivity of pathogens to different anti-infective drugs and provide the most valuable basis for drug selection. The patient ‘ s own situation is also a key consideration when choosing an anti-infection drug. Age, underlying diseases, liver and kidney function, immunisation, etc. affect the metabolic and therapeutic effects of drugs and the possible adverse effects. For example, older persons usually experience a decrease in liver and kidney function, and for drugs metabolismed primarily by liver and kidneys, such as carbacin, vancomicin, etc., doses need to be adjusted to avoid the toxic effects of drug accumulation. In cases where the liver or kidney function is incomplete, the use of drugs that impair the liver or kidney function, such as tetracyclics, sulfamide, etc., should be avoided. Patients with low immune capacity may need to choose a wider and more effective anti-infection drug. The extent and severity of the infection can also influence the choice of drugs. For lung infections, the distribution of pathogens in lung tissue and the permeability of drugs need to be considered. In the case of central nervous system infections, because of the existence of a blood-brain barrier, some drugs are difficult to reach, requiring the choice of drugs that can pass through the blood-brain barrier, such as head spines, meropenan, etc. In the case of serious infections, there may be a need for a joint use of anti-infection drugs to control the situation quickly. Antibacterial spectrometry of drugs is also one of the key factors of choice. Different anti-infection drugs have different antibacterial spectrums. For example, penicillin is primarily effective for gland positives; the antibacterial spectroscopy of peptoxin is gradually expanding with algebra, increasing its effect on gland vaginal bacteria; and quinone-type drugs have some effect on gland positives, glandian cactus and some anaerobics. When choosing a drug, a drug with a corresponding antibacterial spectrum should be selected according to the type of pathogen infected. The adverse effects of drugs should also not be overlooked. Some anti-infection drugs may cause adverse reactions such as allergies, gastrointestinal disorders, damage to liver and kidney function, and neurotoxicity. The choice of drugs needs to be weighed against the effects of treatment and possible adverse effects. For example, fluorophenone-type drugs may affect the cartilage development of children and are therefore not recommended for use in children; sulfamide-type drugs may cause crystall urine and kidney damage and require more water for use. The pharmacological dynamics of drugs also influence choice. Absorption, distribution, metabolic and excretion processes affect the concentration and time of the drug in the body. For example, the absorption of oral drugs may be affected by the gastrointestinal function; some drugs are at higher concentrations in the tissue and are more suitable for use in the treatment of infection in specific areas. In addition, the patient ‘ s past history of medication needs to be taken into account. Reuse of an anti-infection drug should be avoided if the patient has previously been allergic to the drug or if the treatment has failed. At the same time, local pathogen resistance needs to be considered. High drug resistance rates may exist in some regions for certain anti-infection drugs, which may affect drug choice. In short, the choice of anti-infection drugs is a comprehensive process that requires a doctor to make a sound decision, taking into account the specific circumstances of the patient, including the pathogen, his/her own condition, his/her area of infection and the characteristics of the drug, in order to achieve the optimal treatment, while minimizing the occurrence of adverse reactions and resistance.