Summary
Non-small cell lung cancer (NSCLC) is a major type of lung cancer with a high incidence and recurrence rate. The choice of treatment strategy for recurrent non-small cell lung cancer is essential to prolong the survival time and improve the quality of life. Comprehensive treatment strategies for recurrent non-small cell lung cancer, including surgery, radiotherapy and chemotherapy, targeted drug therapy, and immunotherapy, are reviewed in order to provide a reference for clinical decision-making.
Introduction
Non-small cell lung cancer is a major type of lung cancer, accounting for about 80% -85% of all lung cancer. Although with the improvement of medical technology, the treatment of NSCLC is also increasingly rich, but the recurrence rate is still high. Patients with relapsed NSCLC are facing greater treatment challenges. Therefore, it is of great significance to explore and optimize the treatment strategies for relapsed NSCLC to improve the survival rate and quality of life of patients.
Causes and mechanisms
of recurrence
in non-small cell lung cancer The reasons for the recurrence
of non-small cell lung cancer are complex and diverse, including the biological characteristics of tumor cells, incomplete individual differences of patients, tumor microenvironment and other factors. Tumor cell proliferation and invasiveness, residual cells during treatment, inflammatory and immune escape mechanisms in the tumor microenvironment, as well as the age, gender, and genetic background of patients may affect tumor recurrence.
Comprehensive treatment strategy
for
recurrent non-small cell lung cancer
1. Surgical treatment is an effective option for patients with locally recurrent non-small cell lung cancer if their physical condition permits and the tumor does not metastasize extensively. Surgical removal of tumor tissue can control the development of the disease and prolong the survival time. However, because recurrent patients are often accompanied by varying degrees of pulmonary function impairment and increased surgical risk, surgical treatment requires careful assessment of the patient’s physical condition and surgical risk. For patients who are suitable for surgery, they should be closely monitored after surgery and take necessary adjuvant treatment. 2. Radiotherapy and chemotherapy are important treatments for recurrence of non-small cell lung cancer. Radiotherapy destroys tumor cells through high-energy rays, which is suitable for the treatment of locally advanced or recurrent lung cancer. Chemotherapy, on the other hand, uses chemicals to kill the rapid proliferation of cancer cells. However, the side effects of radiotherapy and chemotherapy are greater, which may lead to a decline in the quality of life of patients, so it is necessary to treat patients under the guidance of doctors and closely monitor their physical condition. 3. Targeted drug therapy Targeted drug therapy is a precise attack method designed for tumor surface markers, which can reduce the impact on healthy tissues. For NSCLC patients with specific mutated genes, such as EGFR mutations, targeted drugs can be precisely applied to inhibit the growth and spread of tumor cells. The advantages of targeted drug therapy are definite efficacy and relatively small side effects, but there are problems such as drug resistance and individual differences. 4. Immunotherapy Immunotherapy aims to activate the body’s own immune system, identify and attack cancer cells with lasting anti-tumor activity. Immunotherapy, including monoclonal antibodies and immune checkpoint inhibitors, can control tumors by restoring T cell activity and enhancing anti-tumor effect. However, the efficacy and safety of immunotherapy still need to be further studied and verified. 5. Traditional Chinese medicine treatment plays an important role in the treatment of recurrent NSCLC.
Conclusion
The choice of treatment strategy for
recurrent non-small cell lung cancer has an important impact on the prognosis of patients. The key is to improve the overall therapeutic effect, prolong the survival time of patients and improve the quality of life. In the future, with the deepening of medical research, medical technology is becoming more and more perfect. The treatment of recurrent non-small cell lung cancer will be more diversified and precise, bringing better treatment effect and survival experience to patients. At the same time, strengthening patient education and improving patient compliance are also important factors to improve the therapeutic effect.
