Criteria for the diagnosis of self-inflammatory diseases
Self-inflammatory diseases are a rare group of hereditary diseases, with inflammation due to inherent immune system disorders. Accurate diagnosis is essential for the treatment and management of patients.
I. METHODOLOGY
Detailed information on the symptoms of the patient, including the age, frequency and duration of the first onset. It is understood whether the symptoms are induced by, for example, infection, vaccination, trauma or specific environmental factors. Questions were asked about whether heat is chronically low or cyclically high, and the heat peaks. Attention is paid to the characteristics of the rash, such as form, distribution, and whether it is accompanied by itching or pain. Ask about the symptoms of the joints, including the parts of the joints, the degree of pain, whether there is a related swelling and restriction of activity. It would also be useful to know whether other systems, such as abdominal pain, diarrhoea, chest pain and headache, were experiencing stress. For family history, it is necessary to ask in detail whether there are patients in the family with similar symptoms, as many of their own inflammatory diseases are hereditary.
Medical examination
Comprehensive medical examinations include the examination of skin rashes, red spots, knots, etc., and the observation of rash characteristics, such as the presence of rashes under cold irritation (the cold is associated with its own inflammatory disease). Check if the joints are swollen, swollen or deformed and assess the degree of joint activity. Checks for abdominal pains, hepatic spleen swelling, etc., as some of the self-inflammated diseases may be excruciating and digestive, resulting in hepatic spleen stress. The CPR function is checked for CPR hysteria, respiratory abnormalities, etc., to determine if cardiovascular or respiratory inflammation is severe.
Laboratory inspection
In regular blood tests, attention is paid to white cell count, the proportion of neutral particles, slab count, etc., and some of their own inflammatory diseases can increase or decrease. Blood sunk and C reaction protein reflects the extent of inflammation activity. Anaesthesia tests its own antibodies, most of which are self-inflammated diseases, but help to identify themselves as immune. Specific genetic tests are critical, and many self-inflammatory diseases are caused by genetic mutations, such as the Mediterranean Heat Genome (MEFV) tests for the diagnosis of family Mediterranean heat and the NLRP3 gene tests for the cyclical syndrome associated with the diagnosis of coldin.
Video screening
X-rays can be used to check for arterial bone damage, osteoporosis, etc. Ultrasound examination is of some assistance in the detection of lesions of joints, saplings and abdominal organs. CT and MRI can show more clearly the pathologies of internal organs, central nervous systems and bones, such as those associated with cardiovascular disease in the central nervous system. For patients with suspected inflammatory diseases, the above-mentioned information is analysed to improve the accuracy of the diagnosis and to provide a basis for subsequent treatment.
