In the microworld of the human body, the immune system is supposed to be a faithful guardian of health, but sometimes it is caught in a “civil war”, which is the source of its own immunisation.
Under normal circumstances, the immune system is able to identify “yourself” and “outsiders” with precision. When pathogens such as bacteria, viruses and others are invaded, the immune system is activated quickly, sending immune cells and creating antibodies against external enemies and protecting the body from infection. However, in its own immunisation, the immune system appears to have lost its way, wrongly attacking its tissues and organs as enemies, thus causing a series of symptoms of disease and organizational damage.
In the case of rheumatism arthritis, the immune system attacks the arthropod tissue, causing inflammation, swelling and thickening. Over time, the cartilage and bone of the joint is damaged, and patients feel joint pain, rigidity and restricted activity, which seriously affects the quality of life and even causes disability. A more complex form of self-immunisation, such as systematic red hemorrhoids, can attack multiple systems, including skin, kidney, blood, heart, etc. Patients may experience a wide variety of symptoms, such as facial red spots, oral ulcer, protein urine, anaemia and cardiac arrest, the severity of which varies from person to person, posing considerable challenges to diagnosis and treatment.
The causes of self-immunisation are not yet entirely clear, but research has shown that genetic factors play a role. The presence of certain genes may make it easier for individuals to undergo anomalous regulation of the immune system and increase the risk of disease. However, genetic factors are not the only determinants, and environmental factors are equally critical. For example, viral infections can trigger anomalous responses to the immune system, UV exposure may induce a systematic erythroacemia, and smoking, chemical exposure, stress, etc. may also be associated with the development of self-immunisation.
Anomalous activation of the immune system is the central mechanism for self-immunisation. During normal immunisation responses, the activation of immunosuppressive cells and the production of antibodies are subject to strict regulation, but in the case of self-immunisation, this regulatory mechanism has failed. Self-reactive T-cells and B-cells escaped the immune system’s “censorship” and began to respond to their own antigens, releasing a large number of inflammatory agents, bringing together more immunocellular cells in the pathologies, creating inflammatory responses, constantly attacking and destroying their own tissues.
There is a wide variety of autoimmune diseases, hundreds of which have been identified, and there are wide variations in the manifestations of the symptoms, the mechanisms of morbidity, treatment methods and prognosis. Diagnosis of self-immunisation often requires a combination of the patient ‘ s symptoms, signs, laboratory results and family history, sometimes requiring long-term observations and follow-up visits to make it clear.
The objective of treatment of self-immunisation is primarily to control abnormal activities of the immune system, reduce inflammation response, mitigate symptoms, prevent further development of organ damage and maximize the quality of life of patients. The usual treatment methods include the use of such drugs as sugar cortex hormones, immunosuppressants, biological agents, etc. to regulate the immune system, possibly in conjunction with complementary measures such as physiotherapy and rehabilitation training. However, these treatments often require long-term use and may have some side effects, requiring individualized treatment and management under strict medical guidance.
Self-immunisation is a type of disease caused by an erroneous attack on one ‘ s own organization by the immune system, which imposes a double physical and psychological burden on the patient. As medical research deepens, our understanding of our own immunisation is growing, and we are confident that more effective treatment and prevention strategies will emerge in the future, giving new hope to those suffering from their own immunisation.
