Pyramid antibiotics have played an important role in the field of medicine since their discovery as a class of drugs with unique structures and antibacterial activity. The discovery of polyperidine antibiotics dates back to the middle of the twentieth century. In 1947, for the first time, scientists separated the family of mucus from the mucus sprouts, an early representation of peptide antibiotics. Polycactin includes members such as P.B. and P.E., which have a wide spectrum of antibacterial activity, with a strong inhibitive effect, especially on the Geranella cactus. This finding provided the basis for subsequent studies of polypermium antibiotics.
In the decades that followed, scientists continued to isolate new peptin antibiotics from various organisms. For example, bacterium and bacterium have been separated from mosaic and sprouts of bacterium, which have a high level of antibacterial activity in most of the gelatinian positive bacteria. In addition, Vancocin, as a tricyclic aluminum antibiotics, was isolated in 1956 from the directed chain fungus and has a strong antibacterial effect on the Geran positive.
As research progresses, it has been found that the antibiotics function in a variety of ways, including, inter alia, undermining the integrity of bacterial cellular membranes, inhibiting the synthesis of bacterial cell walls and altering the permeability of bacterial cytones. These unique mechanisms of action make polypylene antibiotics particularly valuable when dealing with drug-resistant microorganisms.
Pyramid antibiotics are widely used clinically, mainly to treat infections caused by sensitive bacteria. For example: 1. Treatment of serious infections: Polymactin B and Polymixin E have been used for the treatment of acute emuscillosis or other gelatinosis infections. Despite the development of new, low-toxic, effective antibiotics, these bacteria can still be a second-selection drug when they are sensitive to other antibiotics. 2. Partial treatment: Due to the toxicity of polyperazine antibiotics, they are not usually the preferred drug for whole-body treatment. However, in local treatments such as the treatment of exterior ear tracts, corneas or skin infections, polypellic antibiotics show good efficacy. In addition, they can be used for urine injection or mist inhalation treatment. 3. Drug-resistant bacterial infections: Vancocin has shown good efficacy in the treatment of patients suffering from serious Gincoccusemia, which is resistant to a variety of antibiotics, and streptococcus endocrinitis, which is allergic to penicillin. Because of the absence of intersectional resistance to VC and other antibiotics, it has become an important drug for the treatment of these resistance infections. 4. Drugs for specific population groups: For special population groups such as children and pregnant women, the use of peptide antibiotics requires caution. For example, there are differences in pharmacinokinetics among newborns, children and adults, and there is a need to adjust the dose and frequency of the drug to the specific circumstances of the patient.
Despite the wide clinical application value of Pyramid antibiotics, there are also some potential toxicity and side effects. For example, polymixin may lead to adverse effects such as neurotoxicity, renal toxicity and neuromuscular conjunction. Therefore, in the use of polypyrene antibiotics, changes in patient condition need to be closely monitored and treatment programmes adjusted in a timely manner.
In addition, as antibiotic resistance becomes more acute, the rational use of polypylene is particularly important. Doctors should select appropriate antibiotics for treatment based on the patient ‘ s specific circumstances, bacterial development and the results of drug-sensitive tests to reduce drug resistance.
Based on the above, polyazine antibiotics play an important role in the field of medicine as a class of drugs with unique structures and antibacterial activity. By in-depth knowledge of their development and clinical applications, we can make better use of these drugs to treat bacterial infections and protect human health.
