Explore new antibacterial techniques and therapies as bacterial resistance evolves and new antibiotics.
The exploration of new antibacterial techniques and therapies faces serious challenges as bacterial resistance continues to develop and new antibiotics become less visible. To meet this challenge, scientists are constantly exploring and developing new antibacterial techniques and therapies. This paper will present several cutting-edge antibacterial techniques and therapies, including new antibiotics, photothermal treatment, intra-cellular disturbance strategies and narrow spectrum antibacterial therapy, with a view to providing the reader with a comprehensive understanding. The development of new antibiotics is taking place in the field of new antibiotics, and new drugs, such as amphibians, polystyrene and nucleic acid, are gradually entering the clinical trial stage. For example, the expansion of the isomerase inhibitor ETA-013 has a wide spectrum of antibacterial activity for a wide range of drug-resistant bacteria and provides new options for the treatment of multiple drug-resistant infections. Similarly, BBL-102, a polysynthesis inhibitor for pelicans, has completed clinical trials and has good antibacterial effects on the Grelan positive and the Grelan cactus. In addition, the nucleic acid synthetic inhibitor AC-75 has been successfully introduced into clinical trials, demonstrating strong antibacterial activity for multiple resistance strains. Photothermal photothermal treatment (PTT) is a micro-creational technology based on photochemical reactions that kills bacteria by converting light energy (usually near infrared light) into thermal energy. PTT ‘ s physical characteristics enable it to avoid resistance when treating bacterial infections, while near-infrared light can penetrate deeper tissues with high internal application prospects. The core of PTT is the development of high-light conversion efficiency nanomaterials, including precious metals, semiconductors, carbon nanomaterials and organic compounds. However, these materials are not specific to bacteria and photothermal effects may cause injury to host cells at the same time as they are microbicide. Therefore, the development of photothermal fungicides with specific characteristics is particularly important. The research team of the Institute of Biomedical Engineering of Suzhou of the Chinese Academy of Sciences has developed a new nano-antibacterial carbon-point BAPTCDs, which combine bacteria with special properties and rapidly warm up under laser exposure, destroy bacterial cell walls and achieve high-efficiency microbicide. The group Von Xinjin of Hunan University on intra-bacterial disturbance strategy developed an anti-bacterial strategy for intra-bacterial disturbances, using the method of self-assembling within the cylindrical cell, to interfere in a general manner with the positioning and functioning of the intrabacterial proteins and to produce a bacterical membrane explosion “from the inside and from the outside”. Such a strategy not only enables the efficient neutralization of a wide range of clinically common bacterial pathogens, but also effectively inhibits the generation of bacterial resistance. The pelican molecules have a high level of biosafety and have demonstrated good therapeutic effects on many bacterial infected animal models. The narrow-spectrum antibacterial therapy can identify and remove target bacteria in a unique manner, thus reducing de-target interference with host symbiotic strains and reducing pressure from bacterial resistance to evolution. However, due to some technical difficulties in distinguishing between fungi and fungi and the lack of investment by pharmaceutical companies in narrow-spectral resistance, the development of narrow-spectral antibacterial therapy has been slow. The team of associate professors of Yang Lihua of the Chinese University of Science and Technology proposed a method of empowering existing broad spectrum antibacterials and treatments to identify target bacteria, thereby transforming them into narrow spectrum antibacterials and therapies. This method uses the nanoballs with a negative charge on the surface to mix with bacteria, which are selectively adsorbed to the fungus surface without adsorbing to the bacterium surface, combining photodynamic effects and efficiently removing the fungus without interfering with the bacterium in light. The continuing exploration and development of new antibacterial technologies and therapies in the final phrase offers new hope and solutions for global public health security. However, these technologies and therapies still require further research and practice to meet the challenge of bacterial resistance. Scientists need to continue to strengthen international cooperation to promote innovation and the development of anti-bacterial technologies, while public awareness of the rational use of medicines should be raised to work together to maintain harmonious coexistence between humans and microorganisms.
