In the field of medicine, HLA-B27 positives are often associated with a strong straight spinal column, but the two cannot simply be equated.
HLA-B27 is an abbreviated human albino B27, a protein that exists on the surface of human cells. A large number of studies have found that HLA-B27 positive rates are high among people with a high degree of direct spinal disease, up to about 90 per cent in some areas. This makes HLA-B27 one of the important genetic markers of direct spina. However, a certain percentage of the general population is also HLA-B27 positive, and the vast majority of them do not suffer from direct spinal disease. According to statistics, only about 2 – 10 per cent of the HLA-B27-positive population will eventually develop into a strong straight spinal column.
This suggests that HLA-B27 positive is only a prompting factor, not the only basis for the identification of a strong straight spinal disease. The diagnosis of direct spinal disease is an integrated process that requires a combination of clinical performance of the patient, visual and other laboratory tests. In clinical terms, patients with direct spinal disease usually experience chronic back pain, which tends to increase after rest and decrease after activity, and may be accompanied by early-morning rigidities, lasting for hours or even full-day periods. As the condition progresses, the activity of the spinal column is gradually limited, with the potential for spinal malformations, such as camelbacks, in serious cases, as well as the stress of some of the patients, such as hips, knee joints, etc., leading to joint pain, swelling and movement disorders. Visual screening also plays a key role in the diagnosis of high-relationship spina. For example, X-rays can detect pathological changes to the hips, with early manifestations of fuzzy joints and bone damage, and at a later stage, with narrow joint gaps, integration, etc.; CT and MRI can show more clearly the pathological details of the hips and spines, which are important for early diagnosis and assessment. In addition, inflammation indicators such as erythrocyte deposition (ESR), C Reaction Protein (CRP) are often on the rise during the period of active direct spinal disease activity, which also helps to assist in the diagnosis and diagnosis of disease activity.
So why does HLA-B27 positive not necessarily mean that it has a high-relative spinal cord? This is because vertical spinal disease is a complex multigenetic genetic disease, and HLA-B27 is just one of many associated genes, although it is more closely associated with direct spinal disease, other genes and environmental factors also play an important role in the development of disease. Environmental factors such as intestinal microbial infections and some traumas may induce a strong straight spinal disease in HLA-B27 positive individuals, but may remain non-pregnant for life for those HLA-B27 positives who do not have the synergy of other contributing factors.
For the HLA-B27-positive population, there is no need for excessive panic, but there is no room for caution. It is recommended that periodic medical examinations be conducted, with particular attention to the state of health of the spinal cord and joints, and that, in the event of suspicious symptoms such as back pains, medical treatment be provided in a timely manner, with a thorough examination and evaluation. HLA-B27 ‘ s positive status does not determine the severity and prognosis of the disease. Actively regulated treatment, including drug treatment, such as the use of inflammatory anti-inflammatory drugs, anti-generative drugs, biological agents etc., as well as a combination of rehabilitation, physical treatment and so forth, is essential to control the condition, improve the quality of life and delay the progress of the disease.
Overall, there is a strong correlation between HLA-B27 positive and high-relationel spinal disease, but this indicator alone cannot be used to identify or exclude strong-relative spinal disease. A proper understanding of the relationship between the two can help to improve the early detection rate of a strong and direct spinal column, so that patients can receive timely and effective treatment and management.
