The rational use of anti-bacterial drugs to avoid drug resistance has the following main points:
I. Correct diagnosis
The first is to determine precisely whether it is bacterial infection. Because many diseases may be caused by viruses, fungi and other pathogens, antibacterial drugs are usually ineffective in these pathogens. For example, common influenza is mostly virus-induced, and the use of antibacterial drugs not only does not treat but may also lead to drug resistance.
ii. Precision drug selection
Antibacterial drugs are selected based on the type of bacteria infected and on the results of sensitive tests. Different bacteria are sensitive to different antibacterials. For example, the treatment of pneumonia caused by pneumocococcal is a more appropriate drug if the bacteria can be found to be sensitive to penicillin through drug-sensitization tests; the blind use of other insensitive antibacterial drugs not only treats poorly but also contributes to bacteria ‘ resistance.
III. Normative use
Use is strictly in accordance with prescribed medical prescriptions and procedures. It is not possible to stop the drug on its own because the symptoms are slightly reduced. For example, a full course of treatment for the use of antibacterial drugs for the infection of the urinary system could be 7 – 14 days, and it would be easy to produce resistance if the use was stopped 3 – 5 days after the symptoms had disappeared and bacteria were not completely eliminated.
To avoid any random change of drugs. In the course of treatment, there are no frequent changes in antibacterial drugs without special reasons (e.g., severe adverse effects or really poor treatment and other factors excluded), as each drug requires a certain amount of time to suppress or eliminate bacteria.
Prevention of abuse
Don’t buy and use antibacterial drugs on your own. The use of antibacterial drugs by many without the guidance of a doctor and on the basis of their own experience is a dangerous act. For example, the use of antibacterial drugs for the treatment of cough in cases where there is no clear bacterial infection increases the risk of resistance.
Preventive use of anti-bacterial drugs is avoided, except in certain medical settings, such as certain surgical procedures, which can reasonably be used to prevent infection. In other non-necessary situations, the preventive use of antibacterial drugs is an important cause of resistance.
When bacteria produce resistance, restoring antibacterial sensitivity is a more complex process.
I. Discontinuation of related drugs
In some cases of drug resistance caused by antibacterial drug abuse, the elimination of the relevant antibacterial drugs for a certain period of time may deprive bacteria of resistance to drug resistance. For example, in a relatively closed bacterial environment (e.g., local infected stoves), the use of drugs that produce resistance to drugs is discontinued, and it is possible that, as the bacteria pass through, some bacteria may regain sensitivity to the drug.
II. Joint use
Co-use of antibacterial drugs using different mechanisms. For example, when bacteria are resistant to a single antibacterial drug, a combination of β-neamide and amino sugar can be used. Because they act separately in the process of the synthesis of bacterial cytowalls and proteins, they can suppress or destroy bacteria from multiple angles and have the potential to overcome the resistance of bacteria.
Antibacterial drugs and resistance inhibitors are used simultaneously. Certain compounds can inhibit bacterial resistance mechanisms, such as the combination of β-implamide inhibitors (clavic acid, schubathan, etc.) and β-implamide antibiotics, and can sensitize bacteria to β-implamide resistance.
III. Development of new antibacterial drugs or therapies
The continued development of new antibacterial drugs is an important strategy to address drug resistance. For example, new types of quinone-type drugs or new antibacterials with new mechanisms of action may be effective for bacteria that are already resistant to traditional drugs.
Explore non-traditional antibacterial therapies, such as cactus. Bacteria are uniquely identified and infected, and in a context of increasing bacterial resistance, their use for the treatment of drug-resistant infections is a promising way of restoring effectiveness in the fight against bacterial infections.
