Membranoous Nephropathy, MN is a renal syndrome that is characterized by the deposition of immunocellular cells on the side of the nephrocyte. After treatment, some patients can achieve clinical relief, but membrane renal disease has a high incidence.I. Overview of membrane kidney diseaseMembrane kidneys are classified as pregenerative and regenerative, the causes of which are unknown, and the rememergic kidneys may be associated with their own immune diseases, infections, drugs, tumours, etc. Typical clinical manifestations of membrane kidney disease include high levels of protein urine, low-protein haemorrhage, oedema and high-lipid haemorrhage.II. Treatment and mitigation of membrane kidney diseasesThe treatment of membrane kidney diseases includes immunosuppressive treatment, treatment of symptoms and lifestyle adjustments. Immunosuppressive treatment is the main method, with sugar-coated hormones, cyclophosphate, takmos, etc. commonly used. After treatment, the patient ‘ s protein urine and kidney function may be improved to achieve clinical relief.III. Re-emergence of membrane kidney diseaseRe-emergence of membrane kidney disease means that, after a period of treatment, the patient is mitigated, but increases in protein urine or other related symptoms are repeated in subsequent follow-up visits. Relapsing is a common problem in the treatment of membrane kidneys.IV. How to judge the recurrence of membrane kidney diseaseMonitoring of protein urine: Proteinuria is the main clinical manifestation of membrane kidney disease and the main indicator of relapse. There are several possible reminders:Increase in the amount of protein urine: The amount of urine is higher than before and usually exceeds 0.5 g/24h or 1 g/24h.Changes in the characterization of urine protein: The characterization of urine protein has changed from negative to positive or has increased from the original positive level.Continual protein urine: Protein urine continues unabated or re-emergence after mitigation.Monitoring of serometry indicators:Clean blood protein: Decline in clean blood protein levels suggesting that there may be a large amount of protein urine.Serum acetic anhydride: An increase in serocal acetic anhydride levels may indicate a reduction in kidney function.Observation of clinical symptoms:Oedema: Symptoms of oedema are present or aggravated in patients.Hematogen abnormalities: increase in serocholesterol and/or triester levels.Kidney test:Renal examination is the gold standard for diagnosing membrane kidney disease and the precise method of determining relapse. Repetition of renal work may be considered if there is a clinical suspicion of recurrence.Treatment after recurrenceRe-evaluation of the condition: In case of suspected recurrence, the patient ‘ s condition should be reassessed, including detailed medical history inquiries, medical examinations and laboratory examinations.Align treatment programmes: Depending on the recurrence, treatment programmes may need to be adjusted, such as increased doses of immunosuppressants or replacement of other immunosuppressants.Close follow-up: After a recurrence, patients need more frequent follow-up visits to monitor changes.Measures to prevent recurrence(b) Upholding treatment: In accordance with medical instructions, do not stop or reduce the medication.(c) Lifestyle adjustment: to maintain a healthy lifestyle and to avoid the risk of relapse caused by labour, infection, etc.Regular follow-up: periodic urine and blood tests are conducted even if the condition is reduced, in order to detect signs of recurrence in a timely manner.ConclusionRe-emergence of membrane kidney disease is an issue requiring close attention during treatment. Re-emergence of membrane kidneys can be effectively judged through regular monitoring of protein urine, serometry indicators and clinical symptoms, and, if necessary, through kidney tests. In the event of recurrence, treatment programmes should be adjusted in a timely manner and preventive measures taken to reduce the risk of recurrence. Patients should maintain good communication with doctors and work together to manage diseases with a view to achieving optimal treatment.
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