How to combat neurotoxicity after breast cancer chemotherapy?
1. Pre-chemical assessment
The risk assessment of CIPN should be conducted before undergoing chemotherapy with neurotoxicity. The incidence of CIPN for breast cancer patients with neurological disorders, diabetes mellitus, smoking, kidney diseases, vitamin deficiency, hypothyroidism, advanced age or family genetic neurosis will increase significantly, and the education of high-risk patients will be strengthened. It is important that the first level of prevention is carried out through, inter alia, changes in the delivery of drugs, drug-types, the use of substitution programmes or the use of nutritional neuropharmaceuticals. In addition, the use of ice-free gloves and ice-free feet to reduce the flow of end-of-pipe body blood, to mitigate the damage to the surrounding nerve, and the use of gloves to prevent neurotoxicity of ioxine.
2. Close monitoring: CIPN ‘ s diagnostic criteria have not yet been established, as its symptoms are not easily detectable at an early stage of chemotherapy and its incidence and severity are often underestimated by patients ‘ failure to report and by under-assessment by physicians. Current monitoring of CIPN is often done through integrated clinical assessment tools (NCI-CTC neurotoxicity classification, mTNS scale, FACT/GOG-Ntx scale) and patient reporting. It is recommended to conduct a full neurological examination before the drug is used to assess the baseline state of the neurofunctional function and to identify patients at higher risk of CIPN. When receiving chemotherapy, breast cancer patients should conduct an assessment of the perineurological variables before and after chemotherapy, and follow up after treatment, identify high-risk patients and increase the frequency of monitoring;
3. Detoxification following medical instructions: Level 1 or 2 CIPN does not need to adjust the dose and 3 degree neurotoxicity requires a stop-up until it is restored to level 2 or less and a drop in the dose in subsequent treatment.
4. Drug treatment. Perceptions of abnormally peripherical neurosis can use trophic neuropharmaceuticals to improve symptoms, such as: B-Vitamins, folic acids and amino acids; and mecobalamine contributes to the sudden regeneration and nervous growth of neuroaxis. The treatment of psychotic rational pain can be based on drugs such as Gabahedin, Pribalin, Dorodrin, and can be supplemented with non-mixed anti-inflammatory drugs. Vitamin E, reductive cythocyte glycerine is an anti-oxygen-resistant drug that accelerates free-base excretion, inhibits the accumulation of drugs in neurons, and accelerates the recovery of neurocell function; Aminophosphate promotes defects, DNA repair, neurotic damage caused by chemotherapy, re-growth and restoration. The saliva acid tetrasalphate neural glucose has the effect of promoting neuroreconstruction. At the same time, the medical treatment CIPN is also in the exploratory phase, and the treatment of Chinese medicine can have some effect on neurotoxic symptoms in the exterior of chemotherapy, such as four inverse soups, five incubated soups and five incinum soups. Numerous studies have shown that Chinese out-of-drugs and acupuncture can reduce the magnitude of the CIPN. In order to reduce neurotoxicity of chemosynthetic drugs, as much as possible should be done to avoid hysteria infusion from the outer ecstasy, and to opt for ecstasy in vitro.
5. Daily care is also affected by the way in which breast cancer is administered, by a single or cumulative dose, by the time of the infusion, by the joint use of a drug. During the course of the chemosynthetic infusion, the nurse, in accordance with the principle of “slow-to-slow” use of the drug, slowly adjusts the rate of the transfer of the chemosynthetic, so it is not appropriate for the patient to adjust its own speed, and during the treatment, the doctor or the nurse should be informed in a timely manner of the symptoms of paralysing and stinging. The following care and health education should be provided for patients at risk of falling: 1) do not wake up in bed for “three and a half minutes”: lie on the bed for a half-minute; sit on the bed under two legs for a half-minute; stand for a half-minute before walking down the bed; 2) use wheelchairs, mobile bed units, etc., should be used with the following care and health education: 1) do not wake up immediately; 2) when using facilities such as wheelchairs, mobile beds, you should fix the brakes and ensure their safety before they are used; 3) a patient who takes a combination of pressure relief, sugar, sleeping pills, urethrins, etc., should inform the patient about the reactions that may occur after the use of medication, such as vertebrates, headaches, etc., and call round people to help; 4) wear appropriate trousers to avoid tripoding; keep the ground clean and waterless, so as to avoid slip; and 5) maintain sufficient indoor lights or light at night, so that the patient is easily placed.
