Is the target drug-resortance all right?
Target drug resistance is a major challenge for cancer treatment. Target-oriented drugs inhibit the growth of tumours by targeting specific molecular targets for cancer cells, however, over time, tumour cells may undergo adaptive changes, leading to drug failure. As an important part of traditional medicine, Chinese medicine plays a role in regulating the body ‘ s immunity and combating tumours. The following explores whether the Chinese drug can reduce drug resistance to the target.
I. Theoretical basis for Chinese-medicine target mitigation and drug resistance
1. Multi-targeting: The complex composition of the medium medicine, which can act on multiple target points and signal access simultaneously, helps to overcome the resistance of tumour cells to single target-oriented drugs.
2. Regulating immunization: Chinese medicine enhances the immune function of the organism and helps the immune system to identify and remove drug-resistant tumour cells.
3. Improving the micro-environment: Chinese medicine may affect the growth and drug resistance of tumour cells by improving micro-tumour environments, such as regulating vascular production and mitigating inflammatory response.
II. POSSIBLE WAYS TO REDUCTION TO DRUG PROHIBITION
1. Inhibition of resistance-related genes: Some Chinese ingredients can inhibit the expression of resistance-related genes in tumour cells, such as multidrug-resistant proteins (MDRs).
2. Enhanced sensitivity of chemotherapy: Chinese drugs can increase the sensitivity of tumour cells to target-oriented drugs and reduce resistance.
3. Inducing cell decay: Certain components of Chinese medicine can induce tumour-resistant cells to collapse and reduce the number of drug-resistant cells.
Examples of Chinese drug applications in reducing drug resistance
1. Yellow Slurpium: Research shows that yellow slurry in yellow Slurpium can reverse the resistance of tumour cells and enhance the effectiveness of chemotherapy.
2. Participation in human tumour Rg3 has been shown to inhibit the growth of tumour cells and to reverse their resistance to target drugs.
3. Artemisin: In addition to its antimalarial effects, artemisinin is found to be tumour-resistant and may help to overcome resistance.
IV. Clinical research on Chinese drug mitigation and drug resistance
Currently, some clinical studies have explored the effects of Chinese drug combinations on drug treatment. The results of these studies suggest that the combination of Chinese drugs with drugs can increase treatment effectiveness to some extent and reduce drug resistance.
V. NOTES
1. The use of Chinese medicine shall be carried out under the guidance of a professional physician and shall avoid adverse interaction with the target drug.
2. The Chinese drug treatment should be individualized and appropriate drugs and doses should be selected according to the patient ‘ s specific circumstances.
3. The efficacy of Chinese drug treatment needs to be tested through scientific research, and it cannot be blindly believed in untested effects.
Challenges and prospects
1. Activity mechanism study: Specific mechanisms for reducing drug resistance from Chinese to Chinese targets are unclear and require further basic research.
2. Quality control: Quality control and standardization of Chinese medicines are key to ensuring the effectiveness of treatment.
3. Clinical trials: Large-scale, multi-centre, random, cross-clinical clinical trials to verify the effectiveness of Chinese medicine in reducing drug resistance to drugs.
Summary
Chinese medicine has some potential and advantages in mitigating drug resistance to the target, but its effectiveness and safety in clinical applications need to be supported by more scientific research and clinical data. In the future, as research on the modernization of Chinese medicine deepens, Chinese medicine is expected to become an effective aid for overcoming drug resistance to the target, providing more treatment options for cancer patients. However, patients should be careful when using Chinese medicine and under the guidance of professional doctors.
