New advances in the treatment of bacterial diarrhoea: rational application of antibiotics and substitution therapy
Abstract: Bacteria-diarrhea is a common intestinal disease worldwide, with a significant impact on patient health. This paper provides an overview of new developments in the treatment of bacterial diarrhoea, focusing on the principles of rational application of antibiotics and emerging substitution therapy, aimed at providing more scientific and effective strategies for clinical treatment, reducing the adverse consequences of antibiotics abuse and increasing the level of treatment for bacterial diarrhoea.
Introduction
Bacteria diarrhoea is intestinal inflammation caused by a variety of bacterial infections, such as coli, salmonella and Shigaella. The main symptoms include diarrhoea, abdominal pain, nausea and vomiting, which can lead to dehydration, electrolytic disorders and even shock in serious cases, threatening the health of patients. Traditional treatment is based on antibiotics, but with the increasing prevalence of antibiotics abuse and the emergence of drug-resistant strains, the search for new treatment methods and strategies has led to the rational application of antibiotics and substitution therapy becoming hot spots for current research.
II. Rational application of antibiotics in the treatment of bacterial diarrhoea
(i) Precision diagnostics and drug sensitivity tests
Accurate diagnosis is essential before antibiotics are used to treat bacterial diarrhoea. Through detailed medical history inquiries, medical examinations and laboratory tests such as excreta routines, bacterial culture and drug sensitivity tests, the pathogen species and their sensitivity to antibiotics are identified. This helps to avoid blind use of antibiotics and reduces the risk of unnecessary use and resistance. For example, in cases of suspected Zhigorella infection, the drug may be selected for targeted treatment if the sensitivity test shows sensitivity to the fluorophenone.
(ii) Selection of appropriate antibiotics and formulation types
Appropriate antibiotics are selected according to the severity of the pathogens and conditions. For mild intestinal infections, lower oral uptake and high local concentrations of antibiotics in the intestinal tract, e.g., Lifushi, are optional. It has better antibacterial activity in the intestinal gland positive and vaginal bacteria and has less adverse overall effects. For serious systemic or specific pathogen infections, highly targeted antibiotics with a wide spectrum, such as third-generation cystasy, are selected, subject to strict drug identification and treatment. In addition, new types of antibiotics, such as intestinal solvents and dilution formulations, are being developed and applied with a view to improving the effects of drugs in the intestinal tract and reducing their overall effects.
(iii) Reasonable therapeutic procedure and dose
The treatment of antibiotics is based on the type of fungi, the severity of the infection and the individual differences of the patient. In general, for acute bacterial diarrhoea, it is still necessary to continue to use drugs after abating symptoms for 1-2 days to ensure the complete elimination of pathogens, but it is not appropriate to be too long to prevent bacterial resistance and an increase in intestinal tract disorders. The dose should be strictly carried out in accordance with the medical instructions or prescriptions, so as to avoid the failure of treatment or the adverse effects of excessive doses due to insufficient doses. For example, in the treatment of bacterial diarrhoea on cyclopropsalt, a dose of 0.25 – 0.75 g per day is commonly used in adults, 2 times a day, and the course of treatment generally lasts 3-5 days.
Alternative treatment for bacterial diarrhoea
(i) Vegetable fungi therapy
Benobacterium is a type of active micro-organism that benefits the host and functions by regulating the micro-ecological balance of the intestinal tract. Common prophylactic strains are bipolar, acidic emulsions, stuporella, etc. They can inhibit the growth and reproduction of pathogens, enhance the intestinal mucous barrier and regulate the intestinal immune response. A number of studies have shown that in the treatment of bacterial diarrhoea, the joint use of prophylactic bacteria can reduce the incidence and symptoms of diarrhoea. For example, the amphibious membranes can significantly improve the excreta and frequency of diarrhoeal patients and increase clinical healing rates. Its mechanisms include, inter alia, the production of organic acids for lower intestinal pH, competition for nutrients, endocrine antibacterials and irritation of intestinal immunoglobins.
(ii) Life-saving therapy
Beneficiary is a group of substances that cannot be absorbed by human ingestion but can be usefully used in the intestinal tract, such as low-polymal fruit sugar, as well as astery. They can selectively stimulate the growth and reproduction of beneficial bacteria in the intestinal tract, thereby improving the intestinal microecological environment. Leafing can produce short-chain fatty acids, lower intestinal pH values and inhibit harmful bacterial growth; increase intestinal mucous genre and protect intestinal mucous membranes; and regulate intestinal creeping to mitigate diarrhoea symptoms. In the prevention and treatment of bacterial diarrhoea, life-savings can be used as a complement and are more effective when used in conjunction with the fungi. For example, in the treatment of bacterial diarrhoea in children, the treatment of a combination of low-polygic sugar can be effective in reducing the duration and recurrence of diarrhoea.
(iii) Bacteria therapy
Bacteria are a type of bacterial virus with a high degree of specificity and self-replicability. As the problem of bacterial resistance has increased, attention has again been given to chromosome therapy. Bacteria for specific pathogens can be identified in the intestinal tract and infected with the corresponding bacteria, leading to bacterial cracking to death, thus removing the infection. Bacteria therapy has the advantage of being specific, less resistant and less influence on normal human population. For example, in the treatment of diarrhea caused by drug-resistant coliform, the use of specific intestinal coliforms can significantly reduce intestinal bacterial loads and mitigate diarrhoea symptoms. However, cactus therapy also faces a number of challenges, such as the narrow host size of the cactus, the internal stability and the pharmaceutical dynamics to be studied further.
(iv) Chinese medicine
Chinese medicine has a long history and extensive experience in the treatment of bacterial diarrhoea. Many Chinese medicines have anti-bacterial, anti-inflammatory, laxative and intestinal functions. For example, yellow-coloured, yellow-breed, and so forth are broad-spectrum resistant and can inhibit the growth of a variety of intestinal pathogens; white-headings have strong inhibitive effects on Shiga and Salmonella, among others. In addition, some combinations of Chinese medicine, such as Gogan’s soup and fragrance, have produced better results in clinical treatment. The mechanism for the role of Chinese medicine is complex and may involve a number of aspects, including the regulation of intestinal immunization, the improvement of intestinal microcycling and the promotion of intestinal mucous membrane restoration. However, the standardization and standardization of Chinese drug treatment needs to be further strengthened to improve the reliability and effectiveness of its clinical applications.
Conclusions
The treatment of bacterial diarrhoea continues to develop and progress. The rational application of antibiotics is an important basis for treatment, which can improve the effectiveness of treatment and reduce the risk of drug resistance through such measures as precision diagnosis, rational choice of drugs, regulation of treatment and dosage. At the same time, the emergence of alternative treatments, such as bacterium, bacterium and Chinese medicine, provides more options for the treatment of bacterial diarrhoea. In clinical practice, treatment strategies that combine antibiotics with substitution therapy should be considered in a holistic manner, taking into account the specific circumstances of the patient, in order to achieve the goal of safer, effective and individualized treatment, to improve patient prognosis and to reduce the rate of relapse. In the future, further in-depth studies are needed on the mechanisms for the functioning of the various treatments, the optimization of treatment programmes and the conduct of large-scale clinical tests to promote the increasing level of treatment for bacterial diarrhoea.
Diarrhoea. Infectious diarrhoea.
