“SMZ” is medically commonly referred to as sulfamethoxazole, which is a long-acting sulfazole antibacterial drug, which is antibacterial for both Grelanc positive and Grelan cacteria, is a broad spectrum of antibiotics and is widely used in clinical practice.
The role of SMZ is primarily to prevent the synthesis of bacteria ‘ nucleic acids and proteins, thereby inhibiting bacteria ‘ growth and reproduction. Specifically, the synthesis of bacterial nucleic acids and proteins requires tetrahydrofolic acid, while the chemical structure of SMZ is similar to that of aminophenate, where SMZ is a raw material for the synthesis of folic acids, and where SMZ is wrongly treated as a combination of ammonia phenylacrylates, the normal synthesis of dihydrofolic acid is not possible, resulting in a lack of tetrahydrofolic acid. In the human body, however, this function has no effect on human cells. Since the human body cannot synthesize folic acid on its own and needs to be supplemented from outside, SMZ does not interfere with normal metabolism of human cells.
The antibacterial resistance of SMZ is broad-spectrum, oral is easily absorbed into the whole body, clinically used mainly for respiratory, intestinal, urinary and other infections caused by sensitive bacteria, rather than for the treatment of tonsite or oscillitis from group A soluble streptococcus, as well as for ricktrosis, husk infections. Due to the widespread use of bacteria and the prevalence of SMZ resistance to drugs, strict enforcement of SMZ antibacterial ailments is required.
Although SMZ is relatively anti-bacterial and has easy oral application, it also has many adverse effects. The most common first is drug allergies, some of which are followed by oral SMZs with drug heat, photo-sensitization, rashes and even serious osmosis multi-form red spots. Therefore, those who have a history of allergies and other drugs should try to avoid their use. In addition, the drug is tritoxic and SMZ is metabolismed by the liver and kidney, which can cause functional damage to the liver, kidney, etc., in the form of an increase in hepatic ammonium enzymes and even the death of his liver cells; kidney damage is manifested in abnormal increases in serocal acetic anhydride and urea nitrogen, especially in the case of water loss and in old age. SMZ inhibits the bone marrow by reducing the number of particle cells, the number of platelets and even the incidence of regenerative obstructive anaemia. In addition, SMZ is degenerative and is prohibited during pregnancy, while a small number of SMZs can be excreted by milk, which can cause nucleotide in the brain of a newborn child up to the age of February, so breastfeeding should also be avoided.
SMZ is a chemically synthesized antibiotics whose chemical properties and structures have an impact on a number of drugs, and more caution is required when co-locating in clinical terms. The ability of SMZ to replace the Wafalin, which is integrated with plasma, increases the free concentration of the Hafarin in plasma, leading to an increased risk of haemorrhage for patients. Therefore, care should be taken when co-locating with anticondensers such as Wafarin, which needs to be reduced. Diabetes diabetics are being used in combination with sugar mellitus, such as Gléban, and SMZ can also replace sugar meds that are combined with plasma protein, increasing the concentration of sugar meds in plasma and increasing the risk of low blood sugar. SMZs are easily deciphered in an acidic environment, which exacerbates the damage to kidney function, and have symptoms such as crystal urine, blood urine, so SMZs are prohibited from sharing with acidic drugs such as vitamin C and as much as possible avoid eating with acidic foods such as Yang Mei, vinegar and acid vegetables. The use of drugs encourages multi-drinking, maintains adequate urine levels and prevents the occurrence of crystallized urine and, if necessary, oral alkaline urine drugs such as sodium carbonate. Other metal ions, such as calcium, magnesium and so on, combined with SMZ to form insoluble compounds, reduce the absorption of drugs and reduce their efficacy. So, during the SMZ, as little food as possible is available, such as nuts, tofu, milk, etc.
In general, SMZ is an effective anti-bacterial drug, provided that it is reasonably administered under the supervision of a doctor to ensure the efficacy of the treatment and the safety of its use.
