Rheumatism arthritis (RA) is a common, self-immunological disease of the whole system, mainly manifested by chronic arthromic dysentery disease, which causes great pain and distress to a large number of patients whose causes have not yet been fully identified, and which is an important subject of continuous in-depth research in the medical community, and some of the following are some of its causes.
First, genetic factors play an unnegligible role in the incidence of rheumatism arthritis. For example, certain equilibria in the human white cell antigen (HLA) genes, such as HLA-DR4, are closely related to the susceptibility to rheumatism arthritis. Individuals carrying such genes, the internal immune system, in response to external irritation, etc., may be more vulnerable to abnormal immunisation responses, leading to a complex pathology process leading to immune attacks and inflammatory reactions in areas such as joint glitch. However, the fact that genetic factors are not the only reasons for determining the occurrence of a disease and that persons with relevant genetic background are not necessarily sick, is only a relatively high probability of a disease, suggesting that there are other factors involved in it.
Secondly, environmental factors are also considered to be one of the important triggers. Infection factors, such as certain bacterial and viral infections, are often highlighted. However, in the course of this process, the immune system may be subject to “judgment” by targeting, for example, its own muscular tissue, which breaks the balance of immunosuppressive tolerance and exposes normal joint tissues to the destruction of their own immunosuppressive cells and immune factors, leading to rheumatological arthritis. In addition, chronic exposure to damp and cold environments can also contribute to changes in the local blood circulation of joints, affecting the metabolism of the tissue around the joints, which indirectly increases the risk of disease, although cold and humidity itself does not directly cause disease, but is an external factor that cannot be ignored.
Moreover, endocrine and metabolic factors also affect the incidence of rheumatism arthritis. Clinical findings show that there are significantly more women than men, especially in women of childbearing age, suggesting that levels of endocrine hormones, such as estrogen, may be associated with disease. Estrogen can affect the functioning of immunocellular cells in the immune system as well as regulate the distribution of cytogens. When endocrine disorders occur and hormone levels are imbalanced, the stability of the immune system is undermined, which may create conditions for the occurrence of rheumatism arthritis. At the same time, a number of metabolic anomalies, such as chronic inflammation caused by obesity, lipid metabolic disorders and so on, can interfere with normal immune control mechanisms in the organism and become a potential “trigger” for disease.
In sum, the causes of rheumatism arthritis are complex and multi-factors, and genetic, environmental, endocrine and metabolic factors interact, which together influence the development of the disease. In the future, more in-depth research is needed to further clarify the mechanisms for the specific role of the factors in order to provide a solid basis for the precise prevention and effective treatment of diseases.
