Supepsis: a deep analysis of a serious emergency.

Septica is a serious infectious complication with high rates of death and morbidity. Understanding the causes of sepsis and its symptoms, diagnostic methods and preventive treatment measures are important for improving the survival and quality of life of patients.A sepsis is a general inflammation syndrome caused by pathogens such as bacteria, fungi, viruses and parasites. Pustotoxicity can further develop into a severe sepsis and sepsis shock, resulting in inadequate functioning of organs, circulatory disorders and even life-threatening conditions. As a result, when sepsis is detected, it is necessary to go to a doctor and treat it, so that treatment is not delayed.The main clinical symptoms of septicaemia include cold warfare, heat (or hypothermia), heart palpitation, rapid breathing and changes in mental state. Patients may even experience symptoms such as reduced blood pressure, accelerated heart rate, rapid breathing and changes in white cell count. Depending on the severity of the condition and the stage of development, the disease can be classified into three main categories: sepsis, sepsis, and sepsis. The diagnosis of sepsis is based on a series of clinical characteristics and biochemical indicators, such as higher or lower body temperature, faster heart rate, rapid breathing and abnormal white cell count.Specifically, the criteria for the diagnosis of sepsis include: body temperature exceeding 38 °C or less than 36 °C; heart rate exceeding 90 °C or two standard deviations above normal values of different ages; breathing or over-breathing more than 20 minutes, with an arterial carbon dioxide fraction pressure below 32 mmHg; or white cell totals normal, but > 10 per cent for mesopolized nuclei, with a blood cell count exceeding 12 × 10 ∧9/L, C-reactive protein (CRP), precalcinin, plasma toxin, serobiology, and serobiological lymphotons, all above the normal two standard deviations.Septics can be caused by infection in any part of the world, and are clinically common in pneumonia, peritonealitis, urinary infections, meningitis, sepsis, etc. They are also common in cases of severe burns, shock, post-surgery diseases, or in cases of chronic underlying diseases such as diabetes mellitus, slow lungs, etc.And who are the good people with sepsis? These are people with infectious diseases, such as acute pericardiitis, severe pneumonia, etc.; people with severe burns, more trauma and post-operative conditions; and people with low levels of immunity, such as the elderly, infants and young children, patients with immunosuppressive diseases and oncology, who are more vulnerable to sepsis.The treatment of sepsis consists mainly of treatments such as early anti-infection treatment, liquid recovery, application of vascular active drugs and organ support. Early anti-infection treatment is key to sepsis treatment, and treatment should be based on clinical experience and the selection of broad-spectrum antibiotics prior to the results of pathogen cultivation. The purpose of the liquid recovery is to correct the low blood capacity of the patient and to keep blood pressure stable. The application of vascularly active drugs helps to improve the micro-cycling of patients and mitigates tissue damage. Organ support treatment, such as mechanical ventilation, blood dialysis, etc., is also required for patients with severe conditions.Prevention of sepsis is more important than treatment. The key to the prevention of sepsis lies in the effective control of the source of infection and the enhancement of physical immunity. In the case of patients with infectious diseases, care should be taken to prevent the spread of the infection. Improved nutritional security and physical strength to prevent infection are particularly important for people with low immunity. In addition, the long-term use or abuse of antibiotics should be avoided, so that “super bacteria” antibiotics are not formed to produce resistance.Septicism is a disease with high mortality and morbidity, which has a significant impact on medical resources and the burden of treatment. According to the World Health Organization report, only half of those discharged with sepsis are fully rehabilitated, 40 per cent will be discharged within 90 days and one third will die within one year. In addition, some survivors suffer from disease-related after-effects, including fatigue, neuromuscular weakness, chronic pain, post-traumatic stress disorder, cognitive disorders, etc.Research on sepsis has made considerable progress over the past few years, but challenges remain. Currently, there are no internationally recognized listed drugs for the treatment of heterosexuals. The application of new and innovative types of drugs in the area of sepsis remains to be strengthened, including the development and detection of advanced technologies and biomarkers for predicting the development and evolution of disease, as well as the acceleration of the distribution and research in this area of advanced therapies such as antibodies, immunotherapy, cell therapy and mRNA products.Quoting 1. Global Septic Alliance Report: providing data and burden analysis on septic global epidemiology2. Karakike E, Giamarellos-Bourboulis E J, Kyprianou M, et al. COVID-19 as cause of viral sepsis: A System Review and Meta-Analysis.3. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis camp: international guidelines for management of sepsis and septic shock 2021.4. Global reporting on the Epidemiology and Burden of sepsis, World Health Organization, 20205. Meghraoui-Kheddar A, et al. Am J Repir Crit Care Med. 2022 Jan 1; 205(1): 46-59 PMID: 3473193. Two new mesophagus sub-teams define an identifiable sepsis characteristic.