In modern Osteomedical practice, the rational use of antibiotics is a key element in ensuring the effectiveness and safety of treatment. Osteoporosis and infections in the treatment process have been the focus of clinical attention, and antibiotics play an indispensable role in the prevention and treatment of these infections.
Preventive use of antibiotics is common for osteoporosis. In clean-up operations, such as the replacement of joints at later stages, although the surgical cut is of a clean type, there is a potential risk of infection due to such factors as the presence of implants during the operation and the length of the operation. The right choice of antibiotics and the right timing of delivery are important at this time. In general, more than 30 minutes to 2 hours before the surgery to remove the skin, intravenous infusion is used as antibiotics. This ensures that, at the beginning of the operation, the level of antibiotics in the patient reaches an effective level and that the bacteria that may enter the incision during the operation can be suppressed in a timely manner from the skin, air, etc. Throughout the operation, the maintenance of effective blood concentration is essential to prevent infection. Moreover, the long-term use of antibiotics is not generally recommended after the operation and, for clean-up operations, a 24-hour stoppage would be more reasonable if there were no special circumstances to avoid unnecessary antibiotics exposure leading to the creation of drug-resistant bacteria.
The situation is even more complicated when it comes to clean-polluting operations, such as open-branding and internal fixation. Open fractures mean that the opening is already in contact with the outside environment, with varying levels of pollution. In such cases, it is first and foremost necessary to undertake a thorough clean-up of the creations. Quality of creation directly affects the incidence of subsequent infections. After creation, antibiotics should be selected on the basis of the level of mouth-to-mouth contamination and the mechanism of injury. In the case of open fractures of light pollution, antibiotics, such as a generation-capacitose fungus, are used experientially for the gland positive bacteria. The usual time for medication is 24 – 48 hours. However, in the case of open fractures that are heavily contaminated, such as soil and excreta, or are treated for longer injuries, the choice of antibiotics, in addition to active incubation, may cover gland cactus and anaerobic bacteria. There may be a need for joint use of anti-aerobic drugs, such as headgills and mitraz, and their use may be extended to 3-5 days, or even longer, and for close observation of the changes in the openings and timely adjustment of the antibiotics to the bacterial culture and drug sensitivity of the anthropogenic agent.
The use of antibiotics is another consideration in the treatment of chronic osteoporosis. Chronic osteoporosis is often the result of incomplete or unsustainable treatment of acute osteoporitis. In this case, the pathology of the local bone and soft tissues has led to the creation of special conditions for the infection of the stoves, including the dead bones, the talisman, etc. Antibiotic use requires long-term, regular and joint use. Sensitivity antibiotics are generally selected on the basis of pre-operative bacterial culture and pharmacological results. It will normally take weeks after ivory infusion, to be replaced by oral antibiotics for several months to completely remove remaining bacteria and prevent re-emergence.
However, the use of osteoporosis must be monitored for drug-resistant bacteria. Unjustified antibiotics use, such as overuse, unregulated combinations, and excessive length of use, can contribute to the production of resistant bacteria. Treatment will become extremely difficult when drug-resistant infections occur and may require the use of higher levels of antibiotics, increasing the medical costs and treatment risks of patients. Therefore, in the use of antibiotics, an osteoporator must strictly follow the relevant guidelines and norms, select the type, dose, route and course of treatment of the antibiotics in a precise manner, taking into account the specific circumstances of the patient, and guarantee the patient ‘ s health while effectively controlling the infection. At the same time, increasing the general education of patients and families on the use of antibiotics and raising their awareness of the rational use of antibiotics will also help to reduce the incidence of antibiotics abuse.
