Tetracyclic antibacterial drugs: knowledge of routine usage and care

Infective diseases occur in daily life and the use of antibacterial drugs is more common. Tetracyclic antibacterial drugs play a role in the treatment of many infections as an important type of antibiotics. But if they are to be used safely and effectively, we need to know in detail how they are used on a day-to-day basis, as well as a lot of attention.I. Common types of tetracyclic antibacterial drugsTetracyclic antibacterials include, inter alia, tetracyclics, thicocin, cinex, Dossicycline, Minocycline, etc. Among them, tetracycline is a typical representative of this type of drug and has a long history of application; Dossi-Cyclogen and Mino-Cyclogen have some advantages in terms of anti-bacterial activity, pharmacological dynamics, and is increasingly used in clinical terms.II. The daily use of type 1. and mode of administration of tetracyclic-type drugs consists of a combination of tablets, capsules, injections, etc. For oral tablets and capsules, it is generally sufficient to deliver them with an appropriate temperature. For example, four epoxy, which is commonly used by adults, is 0.25-0.5g per hour. Dossi Cyclops, with a first dose of 0.2 g, followed by 0.1 g each, 1-2 times a day. Injectives require muscle injection or intravenous dripping by medical professionals in medical institutions in accordance with strict operating procedures. For example, injections of tetracyclic drugs may be used in the treatment of certain serious bacterial infections, but this is relatively rare and requires close monitoring of patients ‘ response. 2. Time takenMost of the tetracyclic drugs are best taken during the abdominal period, as food may affect their absorption. However, there are also some drugs, such as Dossi Cyclones, which are relatively less affected by food and can be taken with food or empty abdominal. In the case of emptiness in the stomach, such as nausea, vomiting and abdominal abdominal pain, it may be considered to be taken about half an hour after the meal, but may slightly reduce the absorption rate and level of the drug.Attention 1. Pregnant and lactating women of restricted groups should avoid the use of tetracyclic drugs. Because such drugs can enter the foetus through a placenta barrier and are deposited into the teeth and bones, leading to the coloring of the foetus ‘ s teeth, poor development of the tooth and inhibiting the growth of the foetus ‘ s bones. During the breastfeeding period, drugs may also enter the infant through milk, with adverse effects on the infant. For example, when pregnant women use tetracyclics, the foetal teeth may appear grey after birth, seriously affecting beauty and dental health. The use of tetracyclic drugs is prohibited for children under the age of 8 years (Dossi and Minocrin can be used with caution in certain special circumstances, but also subject to rigorous evaluation). This is due to the fact that children use tetracyclic drugs during the development of their teeth, which tends to cause permanent change in the color of their teeth and incomplete development of their teeth, commonly referred to as “tetracyclic teeth”. Patients who are allergic to tetracyclic drugs are absolutely not allowed to use them. Allergies may take the form of rashes, itching, respiratory difficulties, allergies, etc., which can endanger life in serious cases. If a patient has had an allergy to a tetracyclic drug, he or she must be informed of his or her treatment so that he or she may choose other suitable antibacterial drugs.2. Drug interactionThe combination of tetracyclic drugs with medicines containing metal ion such as aluminium, calcium and magnesium (e.g., aluminium hydroxide, calcium carbonate, magnesium sulfate, etc.) creates insoluble combinations, reduces the absorption of tetracyclic drugs and thereby reduces their antibacterial efficacy. Therefore, the use of these metallic ion drugs should be avoided within 1-2 hours before and after the administration of the tetracyclic drug. For example, if the patient is taking tetracycline for the treatment of the infection and at the same time is taking aluminium hydroxide because the stomach is not well, then the time between the two will require a reasonable interval.When used in combination with drugs such as Geo-Goxin and Wafalin, tetracyclic drugs may increase their impact. Combining with geo-synthetics may increase the concentration of blood in the body, leading to high-synthesis poisoning and adverse effects such as heart disorders. Therefore, the blood concentration of drugs such as geocoxin would need to be closely monitored at the time of the sharing and the dose adjusted as appropriate.3. Monitoring of adverse effectsGastrointestinal responses are more common, such as nausea, vomiting, diarrhoea and abdominal pain. When symptoms are generally mild, they can be tolerated, but if they are severe and affect the food and nutritional intake of the patient, they should be treated in a timely manner, and doctors may consider adjusting the dose or replacing the drug.The long-term or large-dose use of tetracyclic-type drugs may affect liver function, resulting in aminoase rise, yellow sluice, etc. During the period of use, especially for long-term patients, hepatic function is regularly examined, such as hepatic function indicators every 1-2 weeks, in order to detect liver damage in a timely manner and take appropriate measures.Tetracyclic drugs may also affect the development of teeth and bones (e.g. the effects on children and foetuses mentioned earlier), and in adults, long-term high-dose use may also lead to tanging of teeth and abnormal bone growth, which, although relatively low in relation to children, also requires attention.Tetracyclic antibacterial drugs have a unique place in the treatment of infectious diseases, but we must strictly follow their daily usage and give high priority to related care. Only in this way will it be possible to minimize the occurrence of adverse reactions while playing its anti-bacterial role and to guarantee the safety and health of our medicines. Before using such drugs, doctors or pharmacists must be consulted and must not use them at their own discretion.