Chronic dental haemorrhage is a long-standing haemorrhagic disease in dental tissue, which is complex and often linked to local factors such as toothbrushes, toothstones and systemic factors. Not only does it affect the oral health and beauty of patients, but it may also be the oral expression of certain systemic diseases. Although their treatment is mostly based on local mechanical treatment, the intervention of antibacterial drugs can assist in improving the condition in specific cases. However, the unreasonable use of antibacterial drugs can lead to increased bacterial resistance and micro-ecological imbalance in the mouth, so that the rational use of antibacterial drugs for chronic haemorrhage treatment is of major clinical importance.
I. Causes of and mechanisms for chronic dental haemorrhage: The main cause of chronic haemorrhage is the formation of biofilms of toothbacteria. A bacterial group adhesive to the teeth surface, where bacteria and their metabolites can stimulate dental tissue and trigger inflammatory reactions. As the inflammation continues, the vascular permeability within the tooth aluminum increases, and the cacacia vascular expansion is full of blood, which can easily break up and bleed when it is slightly mechanically irritated (e.g. brushing teeth, feeding, etc.). In addition, the presence of tooth stones further exacerbates the local stimulation of the toothbrush, which provides favourable conditions for the binding of the toothbrush and the continuous damage to the toothbrush tissue on its rough surface. At the same time, a number of systemic factors, such as diseases of the blood system (reduced slabs, leukemia, etc.), endocrine disorders (e.g. changes in hormonal levels during pregnancy) and the long-term use of certain drugs (anti-condensation drugs) may also cause or aggravate chronic haemorrhage in the teeth.
II. The principle of the role of antibacterial drugs in the treatment of chronic tooth haemorrhage: Antibacterial drugs play a role mainly by inhibiting or killing pathogenic microorganisms in tooth-cracking. When haemorrhage occurs in the tooth, local microbial communities are unbalanced and pathogenic bacteria breed in large numbers. For example, common tooth cystasy, mesoplasis, etc. are closely related to chronic tooth diarrhea and dental ecstasy. Antibacterial drugs can interfere with the biological processes of cytowall synthesis, protein synthesis or nucleic acid metabolism of bacteria, thereby reducing the number of bacteria, reducing their irritation to dental tissues, mitigating inflammation, and thus reducing the incidence of haemorrhage.
1. The application of anti-bacterial drugs is serious: joint application of anti-bacterial drugs may be considered when chronic dental haemorrhage is accompanied by visible dental swelling and pus, local bacterial infections are more severe and mechanical post-inflammation disorders, such as pure cleaning and scratching, remain difficult to control effectively. For example, in the case of invasive dental chorus, dental ailments are progressing rapidly and widely, local microorganisms are more toxic and the use of antibacterial drugs helps to control infections quickly. 2. There are all-body susceptibility factors: anti-bacterial drugs can be used as part of a comprehensive treatment to prevent the spread of infection and to promote the rehabilitation of dental tissue in cases where persons with diabetes are exposed to dysentery infection and are not susceptible to healing when blood sugar control is poor, or in cases of chronic organ transplants when there is haemorrhage. 3. Prevention of the spread of infection: Before and after certain oral surgery (e.g. tooth-turning, tooth-picking, etc.), the preventive use of antibacterial drugs can reduce the risk of post-operative infections and reduce complications such as increased haemorrhage caused by infection if the patient himself has a tendency to haemorrhage.
1. Penicillin: for example, amocrin, which has a wide spectrum of antibacterial resistance and a strong virulent virulence, has a good antibacterial activity for most of the greland positive bacteria and some of the grelanes, and has relatively few side effects and is more widely used in oral infections treatment. 2. Haemorrhagic type: For example, the antibacterial spectra overlaps with the penicillin type, but may have better therapeutic effects in some drug-resistant bacteria, with better tissue penetration and effective concentrations in dental tissue. 3. Nitromazole: Metrazine is a common drug for the treatment of anaerobic infections and has special effects on ad hoc anaerobic bacteria such as the thalmium monobicus. The side effects are relatively light and the efficacy of the treatment is comparable or slightly better for the nitrite. 4. The tetracyclic group: Dolphin, for example, has, in addition to antibacterial effects, the function of inhibiting the activity of the metallic metallic protein enzyme, which helps to mitigate the inflammation of the dental tissue and has some advantage in the treatment of chronic dental hysteria.
1. Whole-body delivery: The whole-body delivery of oral or intravenous antibacterial drugs is common for chronic dental haemorrhage patients with a high level of disease and widespread infection. Oral administration is easy to administer, but attention needs to be paid to drug absorption and patient dependence. Intravenous injections allow the drug to rapidly reach effective blood concentration, but there is a medical risk, which needs to be closely monitored by hospitals. The full-body regimen should determine the appropriate dose and course of treatment in the light of the drug ‘ s pharmacological properties, which should not normally be too long in order to avoid bacterial resistance. 2. Locally administered: including venom, local decomposition preparations, etc. A venom containing e.g. chlorine has a specific sorbent, which directly affects dental tissues and toothbacterium spots in the mouth, has the advantage of being user-friendly and of high local drug concentrations, but for relatively short periods. Local decomposition formulations such as gels of ménitrene, menocycline ointment, etc. can slowly release the drug into the toothbag, continue to function as antibacterials, improve local treatments and reduce overall adverse effects.
1. Drug allergies: Before using any antibacterial drugs, patients must be asked in detail about their drug allergies. For patients with an allergy history of drugs such as penicillin and headgillin, the use of appropriate drugs or the careful choice of alternatives should be avoided and the emergency response preparedness for allergies should be prepared. 2. Joint use: The interaction between drugs should be considered when the joint use of multiple antibacterial drugs is required. For example, co-use with some hepatic enzyme inhibitors may increase their blood concentration, leading to increased adverse reactions, while co-use of some antibacterials may create synergies to enhance antibacterial effects, but dose adjustments need to be noted. 3. Adverse effects monitoring: The adverse effects of patients are closely monitored during the use of antibacterial drugs. For example, penicillin can cause allergies, ranging from rashes and itching to severe allergy shock; nitromite can cause gastrointestinal discomfort, odour abnormalities, etc.; long-term use of tetracyclics may affect the development of teeth (children’s patients), cause damage to liver and kidney functions, etc. If the adverse effects are detected, they should be discontinued in a timely manner and appropriate treatment measures taken. Bacteria resistance monitoring: Clinicians should focus on the bacterial resistance in the region and in their own medical institutions and avoid the use of antibacterial drugs with high resistance rates. In the case of chronic dental haemorrhage patients who have suffered from chronic repeated use of anti-bacterial drugs, bacterial development and drug sensitivity testing should be carried out in a timely manner, and drug use programmes should be adapted to the drug-sensitive results in order to improve the effectiveness of treatment and reduce the generation of resistant strains.
Summary: Antibacterial drugs are a double-edged sword in the treatment of chronic dental haemorrhage. The rational choice and proper use of anti-bacterial drugs, with appropriate adaptation certificates, can effectively control local dental infections, reduce haemorrhage and promote the healing of dental tissues. Unreasonable application, however, has many negative consequences, such as increased bacterial resistance and adverse drug effects. Therefore, clinicians need to have an in-depth understanding of the causes of and mechanisms for chronic dental haemorrhage, an accurate understanding of the application of anti-bacterial drugs, their methods of use and their care, and to follow evidence-based medical principles in the treatment process, balancing the advantages and disadvantages in order to optimize the use of antibacterial drugs for chronic tooth haemorrhage treatment, improve the quality of oral care and safeguard the health of patients.
