There are many methods of anti-tumour treatment, among them chemotherapy, which is one of the main treatments, and because of the lack of selectivity between tumour cells and normal cells, the toxic side effects of cytotoxic drugs are multiple and bone marrow inhibition is one of the main side effects. The cytotoxic drugs damage the blood-forming function of the bone marrow, leading to a decrease in the activity and function of the blood stem cells, as shown by the reduction of white cells, erythrocytes and slabs in the blood routines tested. The reduction of white cells causes infection, the reduction of red cells causes anaemia, the reduction of platelets can lead to haemorrhage, and the severe danger to the life of the patient; at the same time, the delay in the delivery of chemotherapy affects the effectiveness of the treatment. Therefore, the timely detection and treatment of bone marrow inhibition is an important part of chemotherapy.
The inhibition of bone marrow by anti-tumour drugs is related to half-life of blood cells. Particle cell half-lives of 6-8 hours, leading to a decrease in the number of particle cells, which is generally believed to begin one week after the chemotherapy stoppage, to reach its lowest point between 10 and 14 days, to rise slowly after a low level of 2-3 days, and to return to normal in 21-28 days and to be U-type. With half-lives of 5-7 days on the plate, the plate dropped slightly later than the particle cell, down to the lowest value in about two weeks, with a rapid decline and a rapid recovery, with a short stay at the bottom of the valley, to the V type. The erythrocyte half-life was 120 days, leading to anaemia.
The degree of bone marrow inhibition caused by different types of chemotherapy is different, both in its occurrence and duration, as well as in its recovery. There is a high degree of bone marrow inhibition for such drugs as vissidol, Gisitabin and Capricorn. The bone marrow is less inhibited by pomegranates, shunpirium, etc. Bone marrow inhibition, such as pheasantol, ghisitabin and shunpa, is fast emerging and recovering, with the lowest reduction in white cells occurring about 1 – 2 weeks after drug use and about 2 – 3 weeks after recovery. The lowest white cell values for drugs such as nitroglycerin and filamentin range from about 3 to 8 weeks and recovery is slow, about 1-2 months. Gisitabin, Lope, can cause a more pronounced drop in the platelets.
How do you understand the post-chemical bone marrow inhibition test? The primary focus is on the indicators of white cell count, meso-particle count, haemoglobin count and slab count, which are more important for particle inhibition than for the total white cell, when these indicators fall below the lower limit of the reference value, as well as bone marrow inhibition. Of course, there is no delay in chemotherapy or complications when bone marrow inhibition occurs. Clinicians are divided into four levels, and general I marrow inhibition does not affect the use of drugs, but it requires close attention to blood patterns. There are two key nodes that require attention, namely, the absolute value of a neutral particle cell below 1.0 x 109/L, and the count of a slab below 50 x 109/L, which are the critical points for the reduction of a third-degree particle and the reduction of a third-degree slab, which are signs of risk of complications and indications of intervention.
With regard to the treatment of post-chemical marrow inhibition, there are a variety of drugs available. Clinicians select different drugs, depending on the degree of bone marrow inhibition and subsequent treatment, for the treatment of white and slabs. If the slab count is <20×109/L and hemorrhage tends, in addition to the drug, the slabs should also be injected and the sepsis drugs applied. Although chemotherapy inhibits erythrocyte precursor cells to the same extent as particle cells and slab precursor cells, due to the longer half-life of the erythrocyte, the decline in hemoglobin is not significant and few people need blood transfusions because of the severe anaemia caused by chemotherapy. When the symptoms of anaemia are evident and the haemoglobin reaches a certain value, red cells can be entered.
