The causes of silver crumb arthritis, a complex self-immunological disease with multiple causes, have not yet been fully identified, but the medical community has made significant progress in the study of a number of factors.
I. Genetic factors: A great deal of research has shown that genetics plays an important role in the incidence of silver crumb arthritis. The family concentrator study found that if there were silver crumbs or silver crumb arthritis in the family, there was a significant increase in the risk of morbidity among other family members. The relevant genetic studies have also identified several genetic sites associated with silver crumb arthritis, such as the HLA-B27 gene, which is positive expression among some silver crumb arthritis patients. Individuals carrying such genes are more vulnerable to immune disorders when triggered by specific environmental factors, which in turn causes silver crumb arthritis. However, not all people with associated genes have an illness, and genetic factors simply provide a potential sensory basis for it.
Immunisation factors: The immunisation system anomalies are at the heart of silver crumb arthritis. Under normal circumstances, the human immune system is able to identify and resist alien pathogens with precision, while maintaining tolerance for its own organization. However, in the case of silver crumb arthritis patients, the immune system is dysfunctional. Among them, T lymphocytes are over-activated, and these active T cells release a large number of inflammatory causes, such as cancer cause of death – α (TNF-α), white cell media – 17 (IL-17), etc. TNF – Alpha promotes the concentration of inflammatory cells in the skin and joints and induces joint glitch cell multiplication, hysterectomy, destruction of joint cartilage and bone; IL – 17 stimulates the excessive growth of horny cells, produces skin filamental changes typical of silver filament, and is also involved in arthritis response and increases joint damage. In addition, the inherent immunocellular cell, such as a tree stucculent cell, is involved, which activates T-cells and further magnifies the immune response, leading to the continued development of the symptoms of silver crumb arthritis.
Environmental factors: Environmental factors play a role in the onset of silver crumb arthritis. Infection is an important environmental trigger, especially upper respiratory infections, such as streptococcal infections. After infection, the aerodynamic immune system is activated, which may break the original immunological balance and make it easier for individuals at genetic susceptibility to have an immuno-mediated inflammatory response, leading to silver crumb arthritis. In addition, skin damage is also associated with the occurrence of silver crumb arthritis, such as severe traumatic events such as sunburns, burns and scratches, which may cause an abnormal immune response in the local skin, which in turn spreads to the joints, leading to arthritis symptoms. Psychological stress is also one of the environmental factors that cannot be ignored, and chronic mental stress, anxiety, depression and other disorders can affect the functioning of the immune system through the neuro-endocrine-immuno-immuno-network system, contributing to the occurrence or exacerbation of silver crumb arthritis.
Other factors: In addition to the main factors mentioned above, there are other factors that may be associated with the incidence of silver crumb arthritis. For example, smoking is an independent risk factor for silver crumb arthritis, which has adverse effects on the immune system, increases in inflammation and is directly related to the severity of the chromosome arthritis. Obesity can also play a role in the incidence of silver crumb arthritis, with many fatty cells in the obese. Inflammations may be involved in the inflammation process, affecting the metabolic and immunological micro-environment of the joints and contributing to the occurrence and development of silver crumb arthritis. In addition, certain drugs, such as lithium, beta-receptor retardants, can induce silver crumb arthritis, which can interfere with the immune control mechanisms in the body, trigger abnormal immune reactions and cause disease.
