Toxicity of drugs used to treat SLE
Systematic erythalamus (SLE) is an autoimmune disease requiring long-term drug control. However, these commonly used drugs for SLE treatment are often accompanied by some toxicity.
Sugar cortex hormones
Sugar cortex hormones are the basic medicine for SLE treatment. The long-term and extensive use of sugar cortex hormones can trigger multiple adverse reactions. In metabolism, it leads to increased blood sugar and increases the risk of diabetes. Many SLE patients need to monitor their blood sugar levels closely after using sugar cortex hormones. At the same time, it can lead to the re-distribution of fat and to obese heart, manifested in special forms such as full moon faces and buffalo backs, which not only affect the appearance of the patient but also exerts stress on the patient ‘ s psychological well-being.
In the skeletal system, sugar cortex hormones induce osteoporosis. The reduced bone density of patients increases the risk of fractures, especially in vertebrates and hips. Long-term use may also affect the growth and development of children’s patients. In addition, sugar cortex hormones weakens the immune function of the organism and increases the vulnerability of patients to various infections, ranging from common respiratory infections to severe opportunistic infections, which pose a serious threat to their life and health.
Immunosuppressants
cyclophosphate is one of the most common immunosuppressants. It has a significant bone marrow inhibition effect, leading to a decrease in the number of blood cells, such as white cells and slabs. This further reduces the patient ‘ s resistance and is prone to bleeding. cyclophosphate may also be toxic to the urology system, causing haemorrhagic bladderitis, and patients suffer from symptoms such as urination frequency, acuteness, pain and blood urine, which seriously affects the quality of life of patients. Long-term use may also affect reproductive function, leading to female ovarian failure, menopause, infertility, etc.
Whether or not mecrophenol is also an immunosuppressant, it can cause gastrointestinal discomfort, such as nausea, vomiting and diarrhoea, and affect the nutritional intake of patients. Some of the patients may also suffer from liver functional damage, as shown by increased aminoase.
Antimalarial drugs
HYCP is a common antimalarial drug for SLE. Although it is relatively safe, it has some toxicity. In the eye, the long-term high-dose use of hydroxychloroquine can cause retinasis, leading to blurred vision and loss of vision. As a result, patients using hydroxychloride need to undergo regular eye examinations, including on the soles, so that eye lesions can be detected at an early stage. In addition, a small number of patients may have adverse skin effects, such as skin skin-colouring and rashes.
Biological agents
With the development of medicine, the use of biological agents in SLE treatment has gradually increased. However, biological agents can also induce infection, particularly the recurrence of latent infections such as nodules. At the same time, local responses to injection areas, such as bruises, pain, etc., may also lead to an allergic reaction, with life-threatening conditions such as an allergic shock for serious persons.
In the treatment of SLE, doctors need to weigh the efficacy and toxicity of the drug, choose the appropriate treatment according to the patient ‘ s specific circumstances, closely monitor the adverse reaction of the drug, adjust the treatment in a timely manner to reduce the harm caused to the patient by drug toxicity, improve the quality of life of the patient and improve the long-term prognosis. Patients themselves also need to be aware of the potential toxicity of the drug and actively cooperate with the examination and treatment adjustments.
