I. Summary of surrogate hyphene
Add cycline is a new form of glyamyl cycline-type antibiotics, a derivative of Minocrin. Its unique chemical structure gives it a wide range of antibacterial activities and has a better antibacterial effect on many drug-resistant bacteria. It is mainly through a combination of 30S and 30S and tRNAs, which prevents ammonium-tRNAs from entering the A level of the nucleus, thus inhibiting the synthesis of bacterial proteins in order to achieve antibacterial effects. This mechanism of action allows it to continue to demonstrate antibacterial resistance in the face of some pathogens that are resistant to traditional antibiotics.
II. Scope of the adaptation certificate for the treatment of infections with cyclohex
(i) Complex abdominal infections
Complex intraperitoneal infections often involve a wide range of pathogens, including eclampella (e.g., coli, creberella, pneumonia, etc.) and gland positive (e.g., intestinal fungi), and possibly anaerobic bacteria. Subcycline is mostly resistant to these common pathogens. In some cases, circabin can be used as an effective treatment option when the patient is suffering from a complex in-bourbon infection due to gastrointestinal perforation, post-operative infections, and when the combination treatment of conventional peptoxin and methazine is ineffective. For example, a 45-year-old male with a diarrhea infection following an abdominal perforation, marked by high heat, abdominal pain and peritoneal inflammation, has been able to develop several times the methoxysilin-yellic fungus (MRSA) and the intestinal edemasis (ESBLs) that produces ultra-spectrum β-ESBLs, with the use of other suitable antibacteric drugs combined with cyclohex, the symptoms of infection are gradually being controlled, body temperature is normal and inflammation indicators are declining.
(ii) Complex skin and soft tissue infections
In the case of complex skin and soft tissue infections, especially those caused by resistant fungus such as methooxin-resistant septococcus (MRSA) and VRE, the surrogate cycline shows an advantage. For example, a diabetic patient with a severe co-infection of a foot ulcer has developed an MRSA and VRE wound, which were previously less effective with a variety of antibiotics, including Vungucin. With the use of surrogate cycline, the haematological pain of the wound is gradually reduced, seepage is reduced and the condition is improved. This is because supercycline can effectively inhibit the growth of these drug-resistant bacteria and prevent further spread of the infection.
(iii) Community access to pneumonia
There is also some application value of surrogate cyclics for those who have acquired sexually transmitted pneumonia in some communities, especially in cases where the pathogen is unknown and is suspected of drug-resistant infections. For example, an elderly patient who is in a more serious condition due to the community ‘ s access to sexually transmitted pneumonia, combined with respiratory failure, has had a poor effect on the conventional treatment of β-intraamide combined Great Encyclopenetrin. Following further examination of the potential for multi-drug-resistant infections, and the introduction of surrogate cyclics in the adapted treatment programme, the patient ‘ s lung infection symptoms have gradually improved and the oxygen cortex has improved, creating conditions for subsequent rehabilitation.
III. Analysis of cases of surrogate circulin treatment of infections
(i) Details of cases
A 62-year-old woman with a severe abdominal infection following an acute cholesterol attack. Patients show high heat, cold fighting, abdominal pain and abdominal swelling, accompanied by nausea and vomiting. Laboratory tests showed a significant increase in the white cell count (20 x 109/L), with a 90% moderate particle cell ratio, C Reactive Protein (CRP) 150 mg/L, calcium reduction (PCT) 2.5ng/mL. The abdominal inductive fluids produce multiple resistance-resistant Boeman non-activated bacterium and cortex.
(ii) Treatment process
Patients use the initial treatment of the acetone-shubattan combined to resist the infection, but this has not worked well and continues to deteriorate. After re-evaluation of medical conditions and drug-sensitive results, the treatment programme was adjusted to include surrogate cycline. The dosage for the use of circulin is based on the recommended formula, with the first dose of 100 mg, followed by 50 mg intravenous drip per 12 hours. Supportive treatment measures, including rehydration and the correction of electrolyte disorders, continue to be maintained.
(iii) The effects of treatment
On the third day after the use of the adhesive cycline, the patient’s body temperature began to decrease and abdominal pain and abdominal swelling were reduced. After 1 week of continued treatment, the body temperature of the patient has largely returned to normal, with the white cell count down to 10 x 109/L, with a neutral particle cell ratio of 70%, CRP 40 mg/L, PCT 0.5ng/mL. The abdominal flow fluids are gradually reduced, and the flow fluids are reviewed for bacteria-free growth. After 2 weeks of intensive treatment, the patient was discharged from hospital.
IV. Attention to the use of cyanide
(i) Negative effects
The adhesive cyclogen, while antibacterial, may have a number of adverse effects, such as gastrointestinal reaction (e.g. nausea, vomiting, diarrhoea). In the course of use, close attention needs to be paid to the patient ‘ s gastrointestinal symptoms and, where necessary, to the dose adjustment or treatment of the condition. In addition, there may be cases of hepatic abnormalities, which require periodic monitoring.
(ii) Reasonable use of medicines
Since cyanide is a specific level of antibiotic use, it should be used with a strict adaptive certificate and avoid further increases in drug-resistant bacteria due to abuse. Based on the results of the drug-sensitization test and the patient ‘ s specific condition, it should not be appropriate to opt for cyclide in the case of mild infections or more appropriate first-line antibiotics. At the same time, attention should be paid to the interaction between drugs in the context of joint use to ensure the safety and effectiveness of treatment.
In general, surrogate cyclics play an important role in the treatment of multiple complex infections, especially drug-resistant infections, but need to be carefully assessed and applied rationally in their use.
