Rheumatism arthritis (RA) is a common self-immunological disease, manifested mainly in chronic inflammation and symmetrical destruction of the joint. However, some RA patients may also suffer internal and environmental damage, which seriously affects their quality of life and their prognosis. The following categories of rheumatological arthritis patients are more likely to suffer internal and environmental damage:
I. Patients whose condition is chronically not under effective control
If rheumatism arthritis is not treated in a timely or ineffective manner, the disease continues to be active and the inflammation factor is released in large numbers over time. These inflammation factors can lead to blood circulation and body organs. For example, the persistence of arthritis can lead to chronic inflammation stress in the body and impaired vascular internal cortex function, which in turn leads to cardiovascular system diseases such as cardiovascular inflammation, heartitis, etc. At the same time, chronic high-inflammation conditions may also affect kidney microvasculars, leading to renal disorders such as renal ball renal inflammation.
II. Patients with abnormal serometry
There is an increased risk of internal and visceral damage to patients with a significantly higher trimester of rheumatogen (RF) and aminopane (CCP). High-drive RF and CCP antibodies indicate a strong immune response from the body itself. Such patients are not only moving at a rapid pace of joint destruction, but are also more vulnerable to lung changes, such as ambulatory pneumonia. Studies have shown that RF-positive and high-drive RA patients are several times more likely to have IPTS than RF-negative patients. Anti-CCP antibodies are also closely related to the occurrence of vascular disease, which can weigh on multiple parts of the body, leading to skin ulcer, neurosis and ischaemic damage to internal organs.
III. Patients with other complications
The combination of other self-immunological diseases, such as systematic erythroacne, dry complexes, etc., has a higher incidence of internal and environmental damage due to more complex and severe immune system disorders. For example, in combination with dry syndrome, patients may suffer from impaired excrete functions, such as saliva, tear glands, in addition to joint symptoms, while renal dystroids are also vulnerable to attack by immunosuppressants, which cause kidney diseases such as renal dystal acid poisoning. In addition, people suffering from rheumatism arthritis, which is a basic disease, such as diabetes mellitus and hypertension, are more likely to suffer from corrosive complications such as heart, brain, kidneys, as these diseases themselves affect the functioning of the blood vessels and organs, with the cumulative effect of RA inflammation. The risk of cardiovascular events such as myocardial infarction and moderate brain posts based on RA-induced vascular inflammation has increased significantly, for example, when diabetes patients suffer from chronic poor blood sugar control, damage to vascular walls and increased blood stickiness.
IV. Geriatric rheumatism arthritis
As age increases, the organ function of the human body declines and the ability to regulate immunization decreases. Old-age rheumatological arthritis patients face their own immuno-inflammation disease, with reduced physical resistance and repair. They are more likely to have lung infections and, in case of lung infections, progress towards severe pneumonia, with severe consequences such as respiratory failure. In cardiovascular terms, there may be basic cardiovascular changes in older patients themselves, such as the sclerosis of arteries, and RA inflammation further accelerates the process of cardiovascular disease, leading to a significant increase in the risk of heart disease such as coronary heart disease and cardiac disorders. In addition, the reduction in liver and kidney metabolic functions of older patients, the slowing down of metabolism and excretion of drugs in the body and the increase in the incidence of adverse drug reactions indirectly increase the risk of internal and internal injuries. For example, in old age, acne anti-inflammation drugs are more likely to cause gastrointestinal haemorrhage and damage to liver and kidney function.
V. Patients with long-term use of certain drugs
The long-term use of sugar-coated hormones to treat patients with rheumatological arthritis, although hormonals have had some effect in mitigating arthritis, has also led to many adverse effects. hormonals can lead to osteoporosis and increase the risk of fracture, as well as potential for gastrointestinal mucous membrane damage, which can induce stomach ulcer, stomach haemorrhage and even stomach perforation. At the same time, long-term hormonal use affects sugar metabolism, leading to increased blood sugar, which in turn increases the risk of diabetes and its complications, with adverse effects on organs such as the cardiovascular system and the kidney. In addition, part of the improvement of the rheumatoids (DMARDs) such as aminotrile, may cause liver damage during long-term use, in the form of aminoase rise, liver fibrosis, etc., and may also affect bone marrow blood function, leading to abnormalities in the blood system such as white cell and small plate reductions, thus increasing the risk of infection and further affecting the functioning of internal organs.
Internal and visceral damage to patients with rheumatological arthritis is the result of a combination of factors. For the above-mentioned high-risk groups, monitoring should be strengthened, more proactive and effective treatment strategies should be adopted, and early intervention should be undertaken to reduce the incidence of internal and environmental damage and improve overall patient prognosis. This requires the development of individualized treatment programmes by rheumatologists in clinical practice, taking into account a combination of the patient ‘ s condition, sero-indicators, complications and treatments.
