Use of antibiotics in intestinal diseases: a prudent and precise treatment strategy
intestinal diseases are a common type of health problem, ranging from infectious diarrhoea to inflammatory intestinal diseases, which are numerous and complex. Antibiotics play an important role in the treatment of intestinal diseases, but they also need to be used carefully to avoid adverse consequences.
In the case of infectious intestinal diseases, such as bacterial dysentery and gastrointestinal inflammation of salmonella infections, the use of antibiotics is often a key treatment. These bacterial infections can cause severe symptoms such as diarrhoea, abdominal pain, fever and, if not controlled in a timely manner, can lead to dehydration, electrolytic disorders and even whole-body infections. At this point, precision in the selection of antibiotics for specific pathogens can rapidly inhibit or kill bacteria, mitigate symptoms and reduce the pathology. For example, for intestinal infections caused by most of the grenylella vaginal bacterium, quinone-like antibiotics often perform good antibacterial effects. However, the use of antibiotics is not without risk. The long-term or inappropriate use of antibiotics can disrupt the balance of the intestinal normal population and give rise to a range of follow-up problems.
There are large and complex microbial communities in the intestinal tract, which are interdependent with the human body and together maintain the normal physiology of the intestinal tract. When antibiotics are used in large quantities, especially in the broad spectrum, they also strike intestines without distinction, while destroying the fungus. This can lead to micro-ecological imbalances in the intestinal tract, which can lead to the proliferation of previously inhibited bacteria, such as hard-to-feeds, leading to antibiotic-related diarrhoea, which can develop to pseudo-film enteritis in severe cases, which are often more persistent and more difficult to treat.
The use of antibiotics is more controversial and complex in the treatment of inflammatory enteritis (e.g. ulcer colonitis and Crone). Inflammatory intestinal diseases are not caused solely by bacterial infections, but are self-immunological diseases involving a number of factors, including genetics, immunisation and the environment. Although intestinal bacteria may play a role in the development of the disease, antibiotics do not cure the disease at its root. In some cases, antibiotics may be used appropriately for targeted treatment when the patient combines intestinal bacterial infections, but the long-term, preventive use of antibiotics is generally not recommended. Studies have shown that the long-term use of antibiotics can further disrupt intestinal immunopathy, exacerbate intestinal inflammation responses and discourage long-term disease control.
With further medical research, there is a growing awareness of the fight against antibiotics in the treatment of intestinal diseases. On the one hand, emphasis is placed on the concept of precision medicine, which, before using antibiotics, identifies pathogen strains by means of excreta training, drug-sensitization tests and selects narrow spectrum, efficient antibiotics to reduce the impact on intestinal microecologicals. On the other hand, there is a growing emphasis on re-establishing the intestinal micro-ecological balance by means of prophylactic, prophylactic or faeces transplants for patients with intestinal micro-ecological imbalances caused by antibiotics. Benobacterium supplements intestinal good bacteria, enhances intestinal barrier function, regulates intestinal immune response, reduces to some extent the side effects of antibiotics and contributes to the recovery of intestinal disease.
Antibiotics are a double-edged sword in intestinal treatment. It is a powerful weapon in the response to infectious intestinal diseases, but it must be used with precision; in the treatment of inflammatory intestinal diseases, it has a limited impact and needs to be weighed carefully. In the future, we look forward to further optimizing the application of antibiotics in intestinal disease treatment through more research and clinical practice and to maximizing the protection of intestinal microecological environments and human health while effectively treating diseases.
