Straight spinal disease is a chronic inflammatory disease with multiple causes.
In terms of genetic factors, it is closely related to the human white cell antigen (HLA-B27). Normally, the immune system is able to identify and launch an attack on an alien pathogen, but when individuals with the HLA-B27 gene encounter certain triggers, the immune system may have an “identification error”. It can attack some of its own organizations, such as those around the spinal joints, as harmful outsiders, thereby causing inflammation. However, not all people with the HLA-B27 gene have an illness, which suggests that the gene simply increases the risk of the disease and requires other factors to work together to cause it.
The infection factor also plays an important role in the onset of a high-intensity spinal disease. Some pathogen infections, such as bacteria, viruses and others, may be contributing factors. For example, some bacterial infections in the intestinal tract. The intestinal strain is a complex ecosystem that can trigger an immune response when the intestinal population is unbalanced, some harmful bacteria are overgrowing or the number of beneficial bacteria is reduced. In responding to intestinal infections, the body ‘ s immune system may produce a cross-response and wrongly attack the spinal joints. In addition, urinary tract infections may be associated. Like trachoma, in some studies it is considered possible to transmit inflammatory signals to, for example, the spinal joint through blood circulation or a local lymphocytic system, thus triggering an abnormal immune response.
In terms of immunosuppressive factors, direct spinal disease is an autoimmune disease. Normal immune systems are able to identify themselves and non-me with precision, but there is a disorder in the immune system among people with a direct spinal column. Immunocellular overactivity releases a large number of inflammatory causes, such as cancer cause of death – α (TNF-α) and white cell media (IL). These inflammation factors constantly stimulate the tissue around the spinal joints, leading to the inflammation of the joints, which in turn causes pain, rigidity, etc. Moreover, over time, inflammation can gradually erode joint cartilage and bones, leading to the integration and straightness of the spinal joint.
Environmental factors also have an impact on the incidence of direct spinal disease. Long periods of cold, humid environments may increase the risk of disease. For example, there is a relatively high incidence among people living in cold and humid areas, or in chronic exposure to cold and humid environments, such as those working in underwater operations and cold storage. This environment may slow the circulation of human blood, strain on muscles around joints, reduce the body ‘ s resistance and make the immune system more vulnerable to anomalies, thus creating the conditions for a disease of a strong straight spinal column.
In conclusion, the incidence of direct spinal disease is the result of a combination of genetic, infectious, immune and environmental factors. The combination of these factors disrupts the normal immune and physiological functioning of the human body and ultimately leads to disease.
